纤溶酶原激活剂抑制物-1基因启动子区4G/5G多态性与血栓性疾病的

被引：13

作者：

富路

孔一慧

李佳

金红

机构：

[1] 哈尔滨医科大学第一临床附属医院心内科,哈尔滨医科大学第一临床附属医院心内科,哈尔滨医科大学第一临床附属医院心内科,哈尔滨医科大学第一临床附属医院心内科

来源：

中华心血管病杂志 | 2001年 / 03期

关键词：

基因,多态性; 纤溶酶原激活剂抑制物1; 血栓;

D O I：

暂无

中图分类号：

R364.15 [];

学科分类号：

摘要：

目的　研究纤溶酶原激活剂抑制物 1(plasminogenactivatorinhibitor 1,PAI 1)基因启动子区单核苷酸插入 /缺失 (4G/ 5G)多态性和血浆PAI 1活性与血栓性疾病之间的关系。方法　病例组 :2 35例有心绞痛史的患者 ,2 0 0例心肌梗死患者 ,71例脑梗塞患者。对照组 :30 2例正常人。分别进行PAI 1基因启动子区 4G/ 5G多态性分析 ,并对其中 116例患者和 90例正常人进行血浆PAI 1活性测定 ,同时检测血糖、血脂、血压、体重指数。用酚、氯仿方法抽提DNA。血浆PAI 1活性测定采用发色底物法。结果　 (1)病例组与对照组比较 ,4G/ 4G基因型频率较高 ,差异有显著性 (P =0 .0 2 2 ) ;(2 ) 4G/5G基因多态性与血浆PAI 1活性存在显著相关性 (P =0 .0 0 1) ,以 4G/ 4G基因型血浆PAI 1活性最高 ;(3)病例组 4G/ 4G基因型的血浆PAI 1活性与血糖、甘油三酯存在相关性 ;(4 ) 4G/ 4G基因型的血浆PAI 1同时与血糖、甘油三酯、胆固醇、体重指数成正相关。结论　病例组 4G/ 4G基因型频率较高 ,血浆PAI 1活性较高 ,其血浆PAI 1活性与血糖、甘油三酯、胆固醇、体重指数存在基因依赖关系 ,是血栓性疾病发病主要原因之一

引用

页码：19 / 22

页数：4

共 11 条

[1]

Juvan-Vague I,Alessi MC.Plasminogen activator inhibitor-1 and atherorombosis. Thrombosis and Haemostasis . 1993

[2]

Juhan-Vague I.Haemostatic parameters and vascular risk. Atherosclerosis .

[3]

Salomaa V,Stinson V,Kark JD.Association of fibrinolytic parameters with early atherosclerosis. Circulation . 1995

[4]

Vawson S,Hamsten A,Wiman B,et al.Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasma plasminogen activator inhibitor-1 activity. Arteriosclerosis and Thrombosis . 1991

[5]

Nicholas OG,Michael W,Mansfield JW,et al.Plasminogen activator inhibitor-1 promoter 4G/5G genotype and plasma levels in relation to a history of myocardial infarction in patients characterized by coronary angiography. Arteriosclerosis Thrombosis and Vascular Biology . 1997

[6]

Gardenan A,Lohre J,Katz N,et al.The 4G/4G genotype of the plasminogen activator inhibitor 4G/5G gene polymorphism is associated with coronary atherosis in patients at high risk for this disease. Thrombosis and Haemostasis . 1999

[7]

Aleessi MC,Peiretti F,Morang P,et al.Production plasminogen activator inhibitor 1 by adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes . 1997

[8]

Ridker PM,Hennekens CH,Lindpainter K,et al.Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men. Circulation . 1997

[9]

Sobel BE.The potential influence of insulin and plasminogen activator inhibitor type 1 on the formation of vulnerable atherosclerotic plaques associated with types 2 diabetes. Proceedings of the Association of American Physicians . 1999

[10]

Mansfield MW,Stickland MH,Grant P J.Enviromental and genetic factors in relation to elevated circulating levels of the plasminogenactivator inhibitor-1 in caucasian patients with non-insulin-dependent diabetes mellitus. Thrombosis and Haemostasis . 1995

← 1 2 →