序贯化疗联合脑放射治疗非小细胞肺癌脑转移

被引:10
作者
陈丽昆
杨群英
梁颖
刘国贞
廖海
徐光川
机构
[1] 中山大学肿瘤防治中心,华南肿瘤学国家重点实验室
关键词
脑转移癌; 肺肿瘤; 序贯化疗; 脑放疗;
D O I
暂无
中图分类号
R734.2 [肺肿瘤]; R739.4 [神经系肿瘤];
学科分类号
100214 ;
摘要
背景与目的脑放疗是非小细胞肺癌脑转移的传统治疗,化疗与脑放疗的联合是近年的研究方向。鉴于序贯/维持化疗近年来在晚期非小细胞肺癌显示较好前景,我们对非小细胞肺癌脑转移患者进行序贯化疗联合脑放射的治疗探索。方法对确诊的非小细胞肺癌脑转移患者采用TP-NP-GP三个方案序贯化疗联合同期的脑放射进行治疗。TP方案:TXT175mg/m2d1,DDP20mg/m2d1-5,每3周重复;NP方案:NVB25mg/m2d1、8,DDP20mg/m2d1-5,每3周重复;GP方案:GEM1g/m2d1、8,DDP20mg/m2d1-5,每3周重复。每个化疗方案至少使用2疗程,有效的患者继续原方案至4疗程后行下一个方案的序贯化疗。结果51例患者使用TP-NP-GP方案序贯化疗在外周病灶的有效率分别为41.2%、35.6%及27.8%,联合同期的脑放射治疗在脑转移灶的有效率达到60.8%。中位生存期14.7个月。1年、2年及3年生存率分别为67.8%、20.6%及1.3%。结论第三代新药方案序贯化疗联合脑放射治疗非小细胞肺癌脑转移可以取得较好疗效,总体耐受性良好。
引用
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页码:896 / 900
页数:5
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