Oxidation degradation of wastewater containing thiosemicarbazide by ClO 2 has been studied.The results indicate that thiosemicarbazide is degradated to the nontoxic inorganics,including SO 2- 4,N 2 and CNO -.It has been proved that the mass ratio of ClO 2 to thiosemicarbazide and pH influence the removal ratio of COD obviously,but reaction time and temperature have weak effect.When pH≤2,R=2.0 and reaction time is 15min,removal ratio of COD achieves the highest value at ordinary temperature.Removal ratio of COD of pesticide wastewater containing thiosemicarbazio is about 86.0% under such condition indicating that the degradation effect is good.