长链非编码RNA与肿瘤的关系及其临床价值

被引：83

作者：

宋皓军

俞秀冲

夏天

郭俊明

肖丙秀

机构：

[1] 宁波大学医学院生物化学与分子生物学教研室

来源：

中国细胞生物学学报 | 2012年 / 34卷 / 07期

关键词：

长链非编码RNA; 肿瘤; 基因表达调控; 肿瘤标志物;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

长链非编码RNA(long non-coding RNA,lncDNA)是指长度超过200个核苷酸、具有调控基因表达作用的非编码RNA。近年来研究表明,长链非编码RNA在肿瘤的发生、发展过程中发挥着促癌或抑癌作用,它们参与了细胞凋亡调控、肿瘤浸润与转移等过程;另外,它们还通过表观遗传调控的方式影响肿瘤细胞的生长。它们有希望成为新型肿瘤标志物和肿瘤治疗的靶点,在肿瘤诊断和治疗方面显示出良好的临床应用前景。

引用

页码：704 / 712

页数：9

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