心理应激在功能性胃肠病发病中的潜在机制

被引：39

作者：

段丽萍

机构：

[1] 北京大学第三医院消化科

来源：

中华消化杂志 | 2011年 / 06期

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

<正>功能性胃肠病(functional gastrointestinal disorder,FGID)是指一组缺乏生化和结构改变的消化系统症状群,在严重或难治性的FGID患者中,精神心理障碍共病的发生率高达42%～61%。50%的肠易激综合征(irritable bowel syndrome,IBS)患者有精神创伤史,其中36%被诊断为创伤后应激综合征(posttraumatic stressdisorder,PTSD)。精神心理应激会影响胃肠道的运动、感觉功能和(或)症状报告倾向,其作用机制复杂,包括:应激源一过性或永久性地改变机体生理功能,进而产生症状;遗传和早期生活应激事

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