血脑屏障上P-糖蛋白与耐药性癫痫关系的研究进展

被引:2
作者
秦开宇 [1 ]
武士京 [1 ]
常津 [2 ]
机构
[1] 天津医科大学总医院神经内科
[2] 天津大学材料学院纳米生物技术研究所
关键词
耐药性癫痫; 血脑屏障; P-糖蛋白; P-糖蛋白抑制剂;
D O I
10.13241/j.cnki.pmb.2007.01.041
中图分类号
R742.1 [癫痫];
学科分类号
摘要
耐药性癫痫是癫痫治疗的瓶颈。P-糖蛋白通过跨膜外排泵作用阻止抗癫痫药物由血脑屏障入脑发挥期望效应是耐药性癫痫产生的重要原因。本文介绍了耐药性癫痫与血脑屏障上P-糖蛋白的相互关系,对目前提出的调节P-糖蛋白功能,改善耐药性癫痫预后应注意的问题进行说明。安全地调节P-糖蛋白功能到适度可能为耐药性癫痫的治疗带来希望。
引用
收藏
页码:123 / 125
页数:3
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