骨髓间充质干细胞向神经细胞的分化

被引：9

作者：

安秀峰

黄汉昌

姜招峰

机构：

[1] 北京联合大学功能食品科学技术研究院生物活性物质与功能食品北京市重点实验室

来源：

生命科学 | 2013年 / 25卷 / 01期

关键词：

骨髓间充质干细胞; 神经细胞; 影响因素;

D O I：

10.13376/j.cbls/2013.01.014

中图分类号：

R329 [人体组织学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

近年来,骨髓间充质干细胞逐渐成为神经科学领域的研究热点,广泛用于治疗神经退行性疾病,其原因是;骨髓间充质干细胞可在诱导物存在下定向分化为有功能的神经元细胞,并能成功表达神经标志蛋白。结合近几年的研究进展,主要从骨髓间充质干细胞的临床试验和应用;激光辐射、氧气含量和神经细胞对骨髓间充质干细胞分化为神经细胞的影响;microRNA、Notch信号通路和Wnt信号通路对骨髓间充质干细胞分化为神经细胞的调节作用等三方面进行阐述。

引用

收藏

页码：84 / 90

页数：7

相关论文

共 18 条

[1]

MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521 [J].

Han, Rui ;

Kan, Quancheng ;

Sun, Yingpu ;

Wang, Shuyang ;

Zhang, Guangyu ;

Peng, Tao ;

Jia, Yanjie .

NEUROSCIENCE LETTERS, 2012, 515 (02) :147-152

[2]

Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study [J].

Mazzini, Letizia ;

Mareschi, Katia ;

Ferrero, Ivana ;

Miglioretti, Massimo ;

Stecco, Alessandro ;

Servo, Serena ;

Carriero, Alessandro ;

Monaco, Francesco ;

Fagioli, Franca .

CYTOTHERAPY, 2012, 14 (01) :56-60

[3]

The effects of low-level laser irradiation on differentiation and proliferation of human bone marrow mesenchymal stem cells into neurons and osteoblasts-an in vitro study [J].

Soleimani, Masoud ;

Abbasnia, Ehsan ;

Fathi, Mehdi ;

Sahraei, Hedayat ;

Fathi, Yashar ;

Kaka, Gholamreza .

LASERS IN MEDICAL SCIENCE, 2012, 27 (02) :423-430

[4]

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions [J].

Ambasudhan, Rajesh ;

Talantova, Maria ;

Coleman, Ronald ;

Yuan, Xu ;

Zhu, Saiyong ;

Lipton, Stuart A. ;

Ding, Sheng .

CELL STEM CELL, 2011, 9 (02) :113-118

[5]

Bone marrow stromal cells as replacement cells for Parkinson's disease: generation of an anatomical but not functional neuronal phenotype [J].

Thomas, Meghan G. ;

Stone, Leah ;

Evill, Lauren ;

Ong, Syerna ;

Ziman, Mel ;

Hool, Livia .

TRANSLATIONAL RESEARCH, 2011, 157 (02) :56-63

[6]

MicroRNA-9 promotes differentiation of mouse bone mesenchymal stem cells into neurons by Notch signaling [J].

Jing, Lijun ;

Jia, Yonglin ;

Lu, Jingjing ;

Han, Rui ;

Li, Jinyi ;

Wang, Shuyang ;

Peng, Tao ;

Jia, Yanjie .

NEUROREPORT, 2011, 22 (05) :206-211

[7]

Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease [J].

Dey, Nicholas D. ;

Bombard, Matthew C. ;

Roland, Bartholomew P. ;

Davidson, Stacy ;

Lu, Ming ;

Rossignol, Julien ;

Sandstrom, Michael I. ;

Skeel, Reid L. ;

Lescaudron, Laurent ;

Dunbar, Gary L. .

BEHAVIOURAL BRAIN RESEARCH, 2010, 214 (02) :193-200

[8]

Effects of Notch-I signalling pathway on differentiation of marrow mesenchymal stem cells into neurons in vitro [J].

Jia Yanjie ;

Sun Jiping ;

Zhou Yan ;

Zhu Xiaofeng ;

Zhang Boai ;

Lian Yajun .

NEUROREPORT, 2007, 18 (14) :1443-1447

[9]

Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation [J].

Baksh, Dolores ;

Boland, Genevieve M. ;

Tuan, Rocky S. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 101 (05) :1109-1124

[10]

Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo [J].

Aleksandrova, M. A. ;

Sukhikh, G. T. ;

Chailakhyan, R. K. ;

Podgornyi, O. V. ;

Marei, M. V. ;

Poltavtseva, R. A. ;

Gerasimov, Yu. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 141 (01) :152-160