代谢综合征及其代谢因子与慢性肾损害相关性的临床研究

被引：26

作者：

边琪

袁伟杰

鲁维维

叶菡洋

崔若兰

机构：

[1] 第二军医大学长海医院肾内科

[2] 第二军医大学长海医院肾内科上海

[3] 上海

来源：

中华肾脏病杂志 | 2005年 / 07期

关键词：

代谢综合征X; 肾功能衰竭; 相关性;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

1002 ; 100210 ;

摘要：

目的探讨代谢综合征及其各组成因子与包括轻度肾损害在内的慢性肾损害的相关性。方法收集我院2003年1月至2003年12月心内科、肾内科和内分泌科符合人选标准的住院患者966例进行回顾性分析。按有、无慢性肾脏病(CKD)或轻度肾损害分组,比较代谢综合征各因素与慢性肾脏损害的关系。统计学处理包括单变量t检验、卡方检验和Logistic多因素回归分析。结果(1)CKD组的年龄、身体质量指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、高血糖、高血压和尿酸水平,冠心病、脑卒中的患病率均高于无CKD组,而高密度脂蛋白(HDL)水平明显低于元CKD组患者;(2)随着代谢综合征因子数量的增多,CKD发病率上升;(3)代谢综合征中各因子并存较各因子单独存在的CKD的危险性增加,与高血糖并存的频率最高;(4)BMI增加也是CKD的重要危险因素;(5)高血糖患者发生轻度肾损害的风险最大(优势比OR=7.698)。结论代谢综合征及其各组成因子是包括轻度肾损害在内的CKD的重要危险因素。随着代谢综合征因子的增多,CKD的危险也随之增加。除了高血糖和高血压,BMI增加也是其中重要的影响因子。

引用

页码：389 / 393

页数：5

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