糖尿病与冠状动脉狭窄程度的关系

被引:1
作者
钱端
姜红
赵君
机构
[1] 中日友好医院心内科
[2] 中建一局四公司医院 北京
[3] 北京
关键词
冠心病; 糖尿病; 冠状动脉造影; 血脂;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
1002 ; 100201 ;
摘要
目的 :探讨糖尿病 (DM)及其危险因素与冠状动脉狭窄程度的关系。方法 :对经冠状动脉造影证实的冠心病住院患者 2 1 4例进行包括血压、吸烟、糖尿病调查及血糖、血总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、载脂蛋白A1(apoA1)和载脂蛋白B(apoB)水平测定 ,对冠状动脉狭窄程度进行定量Gensini评分 ,分析糖尿病及其血脂代谢因素与冠状动脉病变的关系。结果 :合并糖尿病的冠心病患者 (DM CAD)的冠状动脉积分显著高于无糖尿病者 (nonDM CAD) (P <0 .0 1 )。DM CAD的血TG、LDL C、apoB均显著高于nonDM CAD ,而HDL C、apoA1均显著降低 (P <0 .0 1 ,P <0 .0 5 )。DM CAD的年龄、糖尿病病程、收缩压和舒张压及TG、LDL C、apoB与冠状动脉狭窄程度呈显著正相关 (γ =0 .379~ 0 .4 82 ;P <0 .0 5 ,P <0 .0 1 ) ,而nonDM CAD患者中 ,收缩压、舒张压和累计吸烟量也与冠脉积分相关。无论是否合并糖尿病 ,冠心病患者冠状动脉积分与TG、LDL C、apoB呈显著正相关 (γ =0 .4 72~ 0 .4 84 ,P <0 .0 1 ) ,与HDL C和apoA1呈显著负相关 (γ=-0 .35 6~ -0 .330 ,P <0 .0 1 )。多元回归分析发现 ,糖尿病病程、收缩压和舒张压、TC、TG、LDL C与冠状动脉狭窄程度呈显著正相关 (P <
引用
收藏
页码:76 / 79
页数:4
相关论文
共 6 条
[1]  
Determinants of severity and extent of coronary artery disease in patients with type 2 diabetes and in non-diabetic subjects. Syvanne M,Pajunen P,Kahri J,et al. Coronary Artery Disease . 2001
[2]  
The severity of coronary arterosclerosis in type 2 diabetes mellitus is related to the number of circulating triglyceride-rich lipoprotein particles. Tkac I,Kimball BP,Lewis G,et al. Arteriosclerosis and Thrombosis . 1997
[3]  
Angiographic characteristics of coronary artery disease in diabetic patients compared with matched non-diabetic patients. Cariou B,Bonnevie L,Mayaudon H,et al. Diabetes Nutrition Metabolism . 2000
[4]  
Potential mechanism promoting restenosis in diabetes mellitus patients. Aronston D,Bloomgarden Z,Rayfied E,et al. Journal of the American College of Cardiology . 1996
[5]  
A more meaningful scoring system for determining the severity of coronary heart disease. Gensini GG. The American Journal of Cardiology . 1983
[6]  
Does stenting prevent diabetes arterial shrinkage after percutaneous coronary revascularization?. Lincoff A. Circulation . 1997