非HDLC/HDLC与2型糖尿病患者早期颈动脉斑块的相关性

被引：5

作者：

潘清蓉

郑央央

范慧

孙小蒙

王广

徐援

机构：

[1] 首都医科大学附属北京朝阳医院内分泌科

来源：

中国动脉硬化杂志 | 2013年 / 08期

关键词：

非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇; 糖尿病; 颈动脉斑块;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

摘要：

目的评价非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇(非HDLC/HDLC)等血脂指标与2型糖尿病患者早期颈动脉斑块发生的相关性。方法回顾性分析1021例无心脑血管疾病病史的2型糖尿病患者。B超判断颈动脉斑块及测量斑块面积。比较颈动脉斑块组与无斑块组的基本资料、糖尿病病程、糖化血红蛋白、非HDLC/HDLC等血脂比值指标。分析不同血脂指标与颈动脉斑块的相关性。受试者作业特征曲线(ROC)分析非HDLC/HDLC等血脂指标对颈动脉斑块的预测价值。在斑块组,评价非HDLC/HDLC等血脂指标与斑块面积的相关性。结果斑块组男性比率、年龄、糖尿病病程、收缩压、非HDLC、非HDL/HDLC、总胆固醇(TC)/HDLC和LDLC/HDLC显著高于无斑块组,但斑块组的HDLC水平显著低于无斑块组,上述差异有统计学意义(P<0.05)。Logistc回归分析示调整混杂因素后非HDLC水平、非HDLC/HDLC、TC/HDLC和LDLC/HDLC分别是颈动脉斑块的独立危险因素(P<0.05)。LDLC水平在调整混杂因素后与颈动脉斑块无相关性。将非HDLC/HDLC与其他血脂指标的ROC曲线下面积进行比较:非HDLC/HDLC高于LDLC/HDLC、TC/HDLC,但差异接近有统计学意义(P值分别为0.052和0.058)。非HDLC/HDLC显著高于非HDLC和LDLC(P均<0.001)。在斑块组,多元回归分析显示非HDLC/HDLC和LDLC/HDLC是斑块面积的独立影响因子(P<0.05),而非HDLC和TC/HDLC在调整混杂因素后与斑块面积无相关性。结论非HDLC/HDLC是评估2型糖尿病患者早期颈动脉斑块的良好血脂指标。

引用

页码：716 / 720

页数：5

共 16 条

[1] Standards of medical care in diabetes-2013. American Diabetes Association. Diabetes Care . 2013
[2] Clinical usefulness of different lipid measures for prediction of coronary heart disease in type 2 diabetes:a report from the Swedish National Diabetes Register. Eliasson B,Cederholm J,Eeg-Olofsson K,et al. Diabetes Care . 2011
[3] Major lipids,apolipoproteins,and risk of vascular disease.Emerging Risk Factors Collaboration. Di Angelantonio E,Sarwar N,Perry P,et al. The Journal of The American Medical Association . 2009
[4] Non–High-Density Lipoprotein Cholesterol Versus Low-Density Lipoprotein Cholesterol as a Risk Factor for a First Nonfatal Myocardial Infarction[J] . Wildon R. Farwell,Howard D. Sesso,Julie E. Buring,J. Michael Gaziano. &nbspThe American Journal of Cardiology . 2005 (8)
[5] Utility of Non–High-Density Lipoprotein Cholesterol Versus Other Lipoprotein Measures in Detecting Subclinical Atherosclerosis in Young Adults (The Bogalusa Heart Study)[J] . Maria G. Frontini,Sathanur R. Srinivasan,Ji-Hua Xu,Rong Tang,M. Gene Bond,Gerald Berenson. &nbspThe American Journal of Cardiology . 2007 (1)
[6] Ability of traditional lipid ratios and apolipoprotein ratios to predict cardiovascular risk in people with type 2 diabetes
Taskinen, M. -R.
Barter, P. J.
Ehnholm, C.
Sullivan, D. R.
Mann, K.
Simes, J.
Best, J. D.
Hamwood, S.
Keech, A. C.
[J]. DIABETOLOGIA, 2010, 53 (09) : 1846 - 1855
[7] Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients[J] . Naoto Katakami,Hideaki Kaneto,Takeshi Osonoi,Miyoko Saitou,Mitsuyoshi Takahara,Fumie Sakamoto,Kaoru Yamamoto,Tetsuyuki Yasuda,Taka-aki Matsuoka,Munehide Matsuhisa,Yoshimitsu Yamasaki,Iichiro Shimomura. &nbspAtherosclerosis . 2010 (2)
[8] Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: A meta-analysis[J] . Yoichi Inaba,Jennifer A. Chen,Steven R. Bergmann. &nbspAtherosclerosis . 2011 (1)
[9] ESC/EAS Guidelines for the management of dyslipidaemias[J] . . 2011 (12)
[10] Risk Factors for Progression of Carotid Intima-Media Thickness and Total Plaque Area[J] . Marit Herder,Stein Harald Johnsen,Kjell Arne Arntzen,Ellisiv B. Mathiesen. &nbspStroke . 2012 (7)

← 1 2 →