糖尿病视网膜病变:一种非可控性炎症

被引：23

作者：

刘巨平

李筱荣

机构：

[1] 天津医科大学眼科医院

来源：

中华实验眼科杂志 | 2014年 / 32卷 / 01期

关键词：

糖尿病视网膜病变; 非可控性炎症; 炎性因子; 高糖;

D O I：

暂无

中图分类号：

R774.1 [视网膜疾病]; R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学]; 100212 [眼科学];

摘要：

非可控性炎症在多种疾病的发生发展中起到重要作用。糖尿病视网膜病变(DR)是一种低度慢性炎症性疾病,确切地说可能是一种非可控性炎症。DR中的中性粒细胞不能及时凋亡或被清除、不同表型的巨噬细胞同时存在、周细胞功能减弱、Th1细胞反应降低等细胞因素致DR炎症不易缓解。与此同时,抗炎型可溶性因子含量的降低,如白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)、一氧化氮(NO)、环氧化二十碳三烯甘油酸(EETs)、脂氧素等进一步使炎症持续。此外高糖条件下产生的脂质代谢产物、糖基化终末产物、活性氧中间产物(ROI)等持续存在的刺激因素均可导致炎症不能缓解。对DR炎症发病机制的深入理解有助于探索新的治疗途径,延缓其发生发展。

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