NMDAR/PSD-95/nNOS复合物在神经病理性疼痛中的研究进展

被引：11

作者：

刘成全 ^{[1
]}

颜天华 ^{[1
]}

陈荣 ^{[2
]}

机构：

[1] 中国药科大学生理教研室

[2] 江苏欧威医药有限公司

来源：

药学与临床研究 | 2015年 / 23卷 / 02期

关键词：

神经病理性疼痛; NMDAR; PSD-95; nNOS;

D O I：

10.13664/j.cnki.pcr.2015.02.022

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

神经病理性疼痛是一种常见的慢性疼痛疾病,发病机制复杂且临床治疗效果欠佳。最近研究表明,N-甲基-D-天冬氨酸受体/突触后致密蛋白95/神经元型一氧化氮合酶(NMDAR/PSD-95/n NOS)复合物在神经病理性疼痛中发挥重要作用。研究发现,如果不直接抑制NMDAR或n NOS,选择性阻断NMDAR/PSD-95或者n NOS/PSD-95的相互作用,可以在不影响NMDAR和n NOS生理功能的前提下抑制神经病理性疼痛中NO的病理性释放,可能获得没有明显副作用的安全有效的神经病理性疼痛的治疗药物。故本文对NMDAR/PSD-95/n NOS复合物在神经病理性疼痛中的研究进展进行综述。

引用

页码：168 / 171

页数：4

共 13 条

[1]

Epidemiology of Neuropathic Pain and Its Impact on Quality of Life [J].

Smith, Blair H. ;

Torrance, Nicola .

CURRENT PAIN AND HEADACHE REPORTS, 2012, 16 (03) :191-198

[2]

The selective neuronal nitric oxide synthase inhibitor 7-nitroindazole has acute analgesic but not cumulative effects in a rat model of peripheral neuropathy.[J].James Henry;Liliana Dableh.Journal of Pain Research.2011, defa

[3]

A CYCLIC PEPTIDE TARGETED AGAINST PSD-95 BLOCKS CENTRAL SENSITIZATION AND ATTENUATES THERMAL HYPERALGESIA [J].

LeBlanc, B. W. ;

Iwata, M. ;

Mallon, A. P. ;

Rupasinghe, C. N. ;

Goebel, D. J. ;

Marshall, J. ;

Spaller, M. R. ;

Saab, C. Y. .

NEUROSCIENCE, 2010, 167 (02) :490-500

[4]

Disruption of nNOS‐PSD95 protein–protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents.[J].SKFlorio;CLoh;SMHuang;AEIwamaye;KFKitto;KWFowler;JATreiberg;JSHayflick;JMWalker;CAFairbanks;YLai.British Journal of Pharmacology.2009, 2

[5]

Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain [J].

Chen, Shao-Rui ;

Samoriski, Gary ;

Pan, Hui-Lin .

NEUROPHARMACOLOGY, 2009, 57 (02) :121-126

[6]

Neuropathic pain - Redefinition and a grading system for clinical and research purposes [J].

Treede, R. -D. ;

Jensen, T. S. ;

Campbell, J. N. ;

Cruccu, G. ;

Dostrovsky, J. O. ;

Griffin, J. W. ;

Hansson, P. ;

Hughes, R. ;

Nurmikko, T. ;

Serra, J. .

NEUROLOGY, 2008, 70 (18) :1630-1635

[7]

Prevalence of chronic pain with neuropathic characteristics in the general population.[J].Didier Bouhassira;Michel Lantéri-Minet;Nadine Attal;Bernard Laurent;Chantal Touboul.Pain.2007, 3

[8]

Nitric oxide synthase regulation and diversity: Implications in Parkinson's disease [J].

Kavya, Ramkumar ;

Saluja, Rohit ;

Singh, Sarika ;

Dikshit, Madhu .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2006, 15 (04) :280-294

[9]

Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors [J].

Aarts, MM ;

Tymianski, M .

BIOCHEMICAL PHARMACOLOGY, 2003, 66 (06) :877-886

[10]

Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability.[J].Keiko Matsuda;Yoshinori Kamiya;Shinji Matsuda;Michisuke Yuzaki.Molecular Brain Research.2002, 1

← 1 2 →