糖尿病微血管病变分子机制研究进展

被引：22

作者：

杨瑞雪

沈捷

马向华

机构：

[1] 南京医科大学第一附属医院内分泌科

来源：

医学综述 | 2010年 / 16卷 / 20期

关键词：

糖尿病; 微血管病变; 分子机制;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

糖尿病微血管病变是糖尿病患者致死致残的重要原因,其发病基础主要是在各种分子机制介导下,微血管形态、功能发生严重障碍,从而造成组织器官损伤。引起糖尿病微血管病变的机制比较复杂,目前尚未完全阐明。现主要从高血糖相关的葡萄糖毒性产物、血流动力学改变及由上述二者引起的细胞信号转导通路的异常三个方面入手,对糖尿病微血管病变发生机制的研究进展进行综述,为临床的预防和治疗提供依据。

引用

收藏

页码：3136 / 3138

页数：3

相关论文

共 8 条

[1]

Advanced glycation end products and receptor-oxidative stress system in diabetic vascular complications..Yamagishi S;.Ther Apher Dial.2009, 06

[2]

Pleiotropic Effects of Inhibitors of the RAAS in the Diabetic Population: Above and Beyond Blood Pressure Lowering [J].

Ismail, Haisam ;

Mitchell, Rena ;

McFarlane, Samy I. ;

Makaryus, Amgad N. .

CURRENT DIABETES REPORTS, 2010, 10 (01) :32-36

[3]

Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells [J].

Manea, Simona-Adriana ;

Manea, Adrian ;

Heltianu, Constantina .

CELL AND TISSUE RESEARCH, 2010, 340 (01) :71-79

[4]

Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase [J].

Matrougui, Khalid .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2010, 26 (01) :13-16

[5]

OXIDATIVE STRESS, DIABETES, AND DIABETIC COMPLICATIONS [J].

Wei, Wei ;

Liu, Qiuju ;

Tan, Yi ;

Liu, Lucheng ;

Li, Xiaokun ;

Cai, Lu .

HEMOGLOBIN, 2009, 33 (05) :370-377

[6]

Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy [J].

Hara, Tetsuya ;

Ishida, Tatsuro ;

Cangara, Husni M. ;

Hirata, Ken-ichi .

MICROVASCULAR RESEARCH, 2009, 77 (03) :348-355

[7]

Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy [J].

Takebayashi, Kohzo ;

Matsumoto, Sachiko ;

Aso, Yoshimasa ;

Inukai, Toshihiko .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (06) :2214-2217

[8]

Impact of insulin on microvascular blood flow and endothelial cell function in the postprandial state in patients with Type 1 diabetes [J].

Forst, T ;

Forst, S ;

Strunk, K ;

Löbig, M ;

Welter, K ;

Kazda, C ;

Pfutzner, A .

JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2005, 19 (03) :128-132