JAK-STAT信号通路及STAT蛋白在慢性肝病中的研究进展

被引:21
作者
王艳 [1 ,2 ]
高斌 [2 ]
机构
[1] 北京大学第一医院感染疾病科
[2] Laboratory of Liver Diseases,National Institute on Alcohol Abuse and Alcoholism,National Institutes of Health,USA
关键词
STAT转录因子类; 干扰素类; 肝炎,丙型,慢性; 肝肿瘤;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
100201 [内科学];
摘要
<正>1 JAK-STAT通路及其激活和调控1.1 JAK-STAT通路组成JAKs是一类胞浆内可溶性非受体酪氨酸蛋白激酶,分子量在120~140 kD左右。JAKs具有7个保守的同源结构域(JAK homology domain,JH)JH1~JH7。家族中已发现四个成员,即JAK1、JAK2、JAK3和Tyk2。JAKs的底物为STATs,即信号转导子和转录激活子(signal transduc-
引用
收藏
页码:805 / 811
页数:7
相关论文
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