COX-2抑制剂与NSAID联合PPI治疗骨关节病消化道不良反应的Meta分析附视频

被引：7

作者：

杨绍春

机构：

[1] 天津市西青医院

来源：

山东医药 | 2014年 / 04期

关键词：

类风湿关节炎; 骨关节炎; 非甾体消炎药; 质子泵抑制剂; 不良反应; Meta分析;

D O I：

暂无

中图分类号：

R684 [关节疾病及损伤];

学科分类号：

摘要：

目的对COX-2抑制剂与非甾体消炎药(NSAID)联合质子泵抑制剂(PPI)治疗骨关节病的消化道不良反应进行Meta分析。方法计算机检索数据库中关于COX-2抑制剂与NSAID联合PPI治疗骨关节炎(OA)或类风湿关节炎(RA)的临床随机对照研究,截止到2013年4月。采用RevMan5.1软件进行统计分析。结果共纳入高质量前瞻性随机对照研究6篇。Meta分析结果显示,与COX-2抑制剂相比,接受NSAID+PPI治疗者胃十二指肠溃疡、出血发生率差异无统计学意义(OR=0.59,95%CI:0.32～1.08,P=0.09),消化不良症状发生率差异无统计学意义(OR=1.14,95%CI:0.86～1.52,P=0.36)。结论在OA或RA治疗中,COX-2抑制剂与NSAIDs联合PPI胃肠道溃疡或出血、消化不良症状及心血管不良事件发生无明显差异。

引用

页码：70 / 72

页数：3

共 14 条

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