吉兰-巴雷综合征相关空肠弯曲菌脂寡糖基因簇序列分析

被引：1

作者：

姜海 ^{[1
]}

李春岩 ^{[2
]}

顾一心 ^{[1
]}

刘瑞春 ^{[2
]}

张茂俊 ^{[1
]}

张建中 ^{[1
]}

机构：

[1] 中国疾病预防控制中心传染病预防控制所诊断室

[2] 河北医科大学第二医院神经内科

来源：

脑与神经疾病杂志 | 2007年 / 02期

关键词：

吉兰-巴雷综合征; 空肠弯曲菌; 脂寡糖;

D O I：

暂无

中图分类号：

R745.43 [];

学科分类号：

1002 ;

摘要：

目的:分析吉兰-巴雷综合征(Guillain-Barre syndrome,GBS)相关空肠弯曲菌脂寡糖(lipo-oligosaccharides,LOS)基因簇序列特征。方法:利用PCR的方法分段扩增2株GBS相关空肠弯曲菌LOS的生物合成基因簇;对PCR扩增片段克隆测序并对其序列进行初步分析。结果:测序结果发现2株菌LOS基因簇序列为15895bp、12230bp,分别编码19个ORF、13个ORF。与已发表的LOS基因簇序列相比,其中一株为一新的GBS相关菌株LOS合成基因簇类别。结论:参与编码GBS相关空肠弯曲菌LOS生物合成基因簇结构复杂多样,本研究发现了又一种新的GBS相关菌株LOS类别。

引用

页码：98 / 100+112 +112

页数：4

共 7 条

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