核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路在酒精性肝病中的作用

被引：9

作者：

马成 ^{[1
]}

杨慧 ^{[2
]}

机构：

[1] 山西医科大学研究生院

[2] 山西医科大学第一医院感染病科

来源：

临床肝胆病杂志 | 2023年 / 39卷 / 07期

关键词：

肝疾病,酒精性; NF-E2相关因子2; 血红素加氧酶-1; 信号传导;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

酒精性肝病(ALD)在我国的发病率逐年上升，国民的疾病负担日益增加。肝细胞的氧化应激反应是ALD的重要致病机制。核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路是人体重要的内源性抗氧化应激通路，在氧化应激作用下,Nrf2被激活并发挥其转录活性诱导HO-1高表达。HO-1是体内重要的氧化应激反应蛋白，与其血红素酶解产物(胆红素、CO、铁)共同发挥着抗炎、抗氧化及调控细胞凋亡的作用。本文将对近年来Nrf2/HO-1信号通路在ALD中的研究进展进行综述，力求为ALD的发生发展寻找理论依据及治疗切入点。

引用

页码：1708 / 1713

页数：6

共 24 条

[1]

Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress [J].

Liu, Yangwenshu ;

Kuang, Qin ;

Dai, Xianling ;

Zhan, Minxia ;

Zhou, Li ;

Zhu, Liancai ;

Wang, Bochu .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (14)

[2]

Crosstalk between NK cells and hepatic stellate cells in liver fibrosis [J].

Zhang, Yang ;

Wu, Yuan ;

Shen, Wenjuan ;

Wang, Bingyu ;

Yuan, Xingxing .

MOLECULAR MEDICINE REPORTS, 2022, 25 (06)

[3]

Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2 [J].

Hong, Dong-Gyun ;

Song, Ga Yeon ;

Bin Eom, Cheol ;

Ahn, Jae-Hee ;

Kim, Sun Myoung ;

Shim, Aeri ;

Han, Yong-Hyun ;

Roh, Yoon-Seok ;

Han, Chang Yeob ;

Bae, Eun Ju ;

Ko, Hyun-Jeong ;

Yang, Yoon Mee .

FREE RADICAL BIOLOGY AND MEDICINE, 2022, 184 :42-52

[4]

Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders [J].

Ryter, Stefan W. .

ANTIOXIDANTS, 2022, 11 (03)

[5]

Heme Oxygenase-1 Inhibits the Proliferation of Hepatic Stellate Cells by Activating PPARγ and Suppressing NF-κB.[J].Yang Hui;Zhang Li;Chen Jie;Zhang Xiaoqian;Zhao Zhongfu;Zhao Longfeng.Computational and Mathematical Methods in Medicine.2022,

[6]

Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis [J].

Buko, Vyacheslav ;

Zavodnik, Ilya ;

Budryn, Grazyna ;

Zaklos-Szyda, Malgorzata ;

Belonovskaya, Elena ;

Kirko, Siarhei ;

Zyzelewicz, Dorota ;

Zakrzeska, Agnieszka ;

Bakunovich, Aliaksei ;

Rusin, Viktor ;

Moroz, Valentina .

NUTRIENTS, 2021, 13 (11)

[7]

Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction [J].

Zhang, Anqi ;

Suzuki, Takafumi ;

Adachi, Saki ;

Naganuma, Eriko ;

Suzuki, Norio ;

Hosoya, Tomonori ;

Itoh, Ken ;

Sporn, Michael B. ;

Yamamoto, Masayuki .

MOLECULAR AND CELLULAR BIOLOGY, 2021, 41 (11)

[8]

Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation [J].

Ryter, Stefan W. .

CELLS, 2021, 10 (03) :1-25

[9]

Aqueous extract of Polygonatum sibiricum ameliorates ethanol‐induced mice liver injury via regulation of the Nrf2/ARE pathway.[J].Wang Guangjun;Fu Youwei;Li Jiujiu;Li Yanni;Zhao Qihong;Hu Anla;Xu Chuande;Shao Dongliang;Chen Wenjun.Journal of Food Biochemistry.2020, 1

[10]

Alcoholic hepatitis and metabolic disturbance in female mice : a more tractable model than <i>Nrf2-/-</i> animals..[J].Sheriff Lozan;Khan Reenam S;Saborano Raquel;Wilkin Richard;Luu NguyetThin;Gunther Ulrich L;Hubscher Stefan G;Newsome Philip N;Lalor Patricia F.Disease models & mechanisms.2020, 12

← 1 2 3 →