醛固酮拮抗剂在顽固性高血压治疗中的地位

被引:23
作者
李琳
陈良华
宋尚明
刘同宝
机构
[1] 山东大学附属省立医院心内科
关键词
顽固性高血压; 醛固酮; 螺内酯; 依普利酮;
D O I
暂无
中图分类号
R544.1 [高血压];
学科分类号
1002 ; 100201 ;
摘要
对于顽固性高血压患者,无论是否伴有明显的血醛固酮增多,在监测血钾及药物不良反应的条件下,加用小剂量醛固酮拮抗剂可得到意想不到的降压效果以及保护靶器官的作用。现将通过近年多项相关临床试验,探讨醛固酮拮抗剂在顽固性高血压治疗中的地位。
引用
收藏
页码:55 / 58
页数:4
相关论文
共 11 条
[1]  
Sleep Apnea, Aldosterone, and Resistant Hypertension[J] . Eduardo Pimenta,David A. Calhoun,Suzanne Oparil.Progress in Cardiovascular Diseases . 2009 (5)
[2]  
Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway[J] . Vijay Koka,Xiao Ru Huang,Arthur C.K. Chung,Wansheng Wang,Luan D. Truong,Hui Yao Lan.The American Journal of Pathology . 2008 (5)
[3]  
Resistant Hypertension: Identifying Causes and Optimizing Treatment Regimens[J] . Cora Lynn B. Trewet,Michael E. Ernst.Southern Medical Journal . 2008 (2)
[4]   A comparison of the aldosterone-blocking agents eplerenone and spironolactone [J].
Struthers, Allan ;
Krum, Henry ;
Williams, Gordon H. .
CLINICAL CARDIOLOGY, 2008, 31 (04) :153-158
[5]   Effect of spironolactone on blood pressure in subjects with resistant hypertension [J].
Chapman, Neil ;
Dobson, Joanna ;
Wilson, Sarah ;
Dahlof, Bjorn ;
Sever, Peter S. ;
Wedel, Hans ;
Poulter, Neil R. .
HYPERTENSION, 2007, 49 (04) :839-845
[6]   Effects of eplerenone versus losartan in patients with low-renin hypertension [J].
Weinberger, MH ;
White, WB ;
Ruilope, LM ;
MacDonald, TM ;
Davidson, RC ;
Roniker, B ;
Patrick, JL ;
Krause, SL .
AMERICAN HEART JOURNAL, 2005, 150 (03) :426-433
[7]   Does aldosterone-to-renin ratio predict the antihypertensive effect of the aldosterone antagonist spironolactone? [J].
Mahmud, A ;
Mahgoub, M ;
Hall, M ;
Feely, J .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (12) :1631-1635
[8]   Efficacy of low-dose spironolactone in subjects with resistant hypertension [J].
Nishizaka, MK ;
Zaman, MA ;
Calhoun, DA .
AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (11) :925-930
[9]   The role of spironolactone in the treatment of patients with refractory hypertension [J].
Ouzan, J ;
Pérault, C ;
Lincoff, AM ;
Carré, E ;
Mertes, M .
AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (04) :333-339
[10]  
Interactions of mineralocorticoids and glucocorti-coids in epithelial target tissues revisited. Morris DJ,Latif SA,Brem AS. Steroids . 2009