细胞因子在重症哮喘发病机制中的研究进展

被引：8

作者：

彭玲玲

段婷婷

陈艳焦

王宇

徐玉东

杨永清

尹磊淼

机构：

[1] 上海中医药大学上海市针灸经络研究所

来源：

现代生物医学进展 | 2018年 / 18卷 / 10期

关键词：

重症哮喘; 细胞因子; 中性粒细胞; 治疗;

D O I：

10.13241/j.cnki.pmb.2018.10.039

中图分类号：

R562.25 [];

学科分类号：

摘要：

重症哮喘是指在过去一年中超过50%的时间需要给予高剂量糖皮质激素联合长效β2-受体激动剂和白三烯调节剂或全身激素治疗,才能维持哮喘控制或即使在上述治疗下仍不能有效控制症状的疾病。重症哮喘发病机制复杂,危险因素多,治疗困难,是临床热点和难点问题。免疫介导的炎症反应在重症哮喘疾病发生中处于重要地位,多种炎症细胞和前炎性因子介导的免疫应激均参与了重症哮喘的发生和发展。本综述对细胞因子的表达与重症哮喘炎症病理改变做了分析,有助于深入研究重症哮喘发病机制,以期为临床诊断和寻找更为有效的靶向治疗药物提供新的理论依据和策略。

引用

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页码：1990 / 1995

页数：6

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