3,4′,5-三羟基芪-3-β-单-D-葡萄糖苷对血管内皮前列环素的影响与血小板聚集的关系(英文)

被引：2

作者：

张佩文

余传林

王耀忠

骆苏芳

孙莉莎

李锐松

机构：

[1] 第一军医大学药理教研室

[2] 第一军医大学药理教研室广州中国

[3] 广州中国

[4] 广州

来源：

ActaPharmacologicaSinica | 1995年 / 03期

关键词：

3,4′,5-三羟基芪-3-β-单-D-葡萄糖苷; 白藜芦醇苷; 脐静脉; 血管内皮; 血小板聚集; 血栓素A2; 栓素B2; 前列环素; 6-酮前列环素F1 alpha;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的:探讨3,4′,5-三羟基芪-3-β-单-D-葡萄糖苷（polydatin,Pol）抑制血小板聚集与其使血管内皮释放前列环素作用间的关系.方法:Pol与培养的人脐静脉内皮细胞（VEC,酶消化法）孵育为内皮组,无VEC为对照组,移细胞培养液至兔血小板（洗涤法）,测凝血酶诱聚后血小板聚集率（PAR,比浊法）及上清液6-酮-前列环素F1alpha(6-keto-PGF1α),血栓烷B2（TXB2）含量（放免法）.结果:无VEC组Pol不减少PAR;VEC组0.41 mmol·L-110 minPAR减少（-10±10）,6-keto-PGF1α增加(108±30 ng·L-1)(各与蒸馏水组之2±12,54±20ng·L-1比).结论:Pol抑制血小板聚集与其增加VEC前列环素释放有关.

引用

页码：75 / 78

页数：4

共 7 条

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