炎症因子在酒精性肝病发生发展中的作用

被引：38

作者：

邱媛媛

王伟恒

朱樑

机构：

[1] 第二军医大学附属长征医院消化科

来源：

临床肝胆病杂志 | 2016年 / 03期

关键词：

肝疾病,酒精性; 肿瘤坏死因子α; 白细胞介素6; 白细胞介素10; 综述;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

酒精性肝病(ALD)是全球范围内引起肝损伤的最常见疾病。炎症反应是引起ALD肝损伤的重要原因。酒精入肠后可使肠源性内毒素经肝肠循环入血增多,进而激活肝脏Kupffer细胞中Toll样受体4引起炎症因子的释放。肿瘤坏死因子α等炎症因子引起肝损伤,而白细胞介素(IL)6、10等通过调节炎症反应起到保护肝脏的作用。其中IL-6通过激活信号转导和转录激活因子(STAT)3通路上调肝细胞中多种抗损伤基因的表达,IL-10通过激活Kupffer细胞中STAT3抑制肝脏炎症反应。促炎因子和抗炎因子的失衡和再平衡的过程就是ALD的发展和转归过程。从炎症反应角度系统的综述了炎症因子在ALD发生发展中的作用。

引用

页码：574 / 578

页数：5

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