中药绿原酸的研究进展

被引：101

作者：

王丽萍

郭栋

王果

周宏灏

机构：

[1] 中南大学临床药理研究所

来源：

时珍国医国药 | 2011年 / 22卷 / 04期

关键词：

绿原酸; 药物代谢动力学; 药物效应学;

D O I：

暂无

中图分类号：

R284.1 [化学分析与鉴定];

学科分类号：

100804 [中药化学];

摘要：

绿原酸存在于多种植物中。文章从它的吸收、分布、代谢、排泄等药物代谢动力学和抗炎、抗肿瘤、抗菌、抗心血管疾病、抗氧化降血糖等药物效应学等方面对其进行阐述,并对绿原酸的发展前景进行展望。

引用

页码：961 / 963

页数：3

共 5 条

[1]

Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-κB and JNK/AP-1 activation [J].

Shan, Jianhua ;

Fu, Jin ;

Zhao, Zhihui ;

Kong, Xiuqin ;

Huang, Huang ;

Luo, Lan ;

Yin, Zhimin .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2009, 9 (09) :1042-1048

[2]

Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans1;2.[J].Farah; Adriana;Monteiro; Mariana;Donangelo; Carmen M;Lafay; Sophie.The Journal of Nutrition.2008, 12

[3]

Chlorogenic acid is poorly absorbed, independently of the food matrix:: A Caco-2 cells and rat chronic absorption study [J].

Dupas, Coralie ;

Baglieri, Agnes Marsset ;

Ordonaud, Claire ;

Tome, Daniel ;

Maillard, Marie-Noelle .

MOLECULAR NUTRITION & FOOD RESEARCH, 2006, 50 (11) :1053-1060

[4]

Oxidative metabolism of 5-o-caffeoylquinic acid (chlorogenic acid), a bioactive natural product, by metalloporphyrin and rat liver mitochondria [J].

dos Santos, MD ;

Martins, PR ;

dos Santos, PA ;

Bortocan, R ;

Iamamoto, Y ;

Lopes, NP .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2005, 26 (01) :62-70

[5]

A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor:: Isolation and identification from methanol extract of Euonymus alatus [J].

Jin, UH ;

Lee, JY ;

Kang, SK ;

Kim, JK ;

Park, WH ;

Kim, JG ;

Moon, SK ;

Kim, CH .

LIFE SCIENCES, 2005, 77 (22) :2760-2769

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