代谢组学及其在临床中的应用

被引：6

作者：

康媛

李笑天

机构：

[1] 复旦大学附属妇产科医院

来源：

国外医学(妇产科学分册) | 2007年 / 04期

关键词：

代谢组学; 核磁共振; 质谱; 色谱; 疾病诊断;

D O I：

暂无

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

代谢组学是继基因组学、蛋白质组学、转录组学后出现的新兴"组学"。代谢组学以基因表达的最终产物(小分子代谢物)为研究对象,主要运用核磁共振、质谱、色谱等技术分离纯化得到数据,并用模式识别技术分析数据,获取有用信息。研究生物体系的代谢网络,代谢组学各单一技术平台均存在一定局限性。代谢组学是系统生物学的组成部分,在临床应用中有广阔的前景,目前代谢组学已广泛应用于疾病诊断、发病机制研究、治疗监测等领域。

引用

页码：272 / 275

页数：4

共 9 条

[1]

Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model[J] . Michael S. Hodavance,Sarah L. Ralston,István Pelczer.Analytical and Bioanalytical Chemistry . 2007 (2)

[2] Applying biofluid 1H NMR-based metabonomic techniques to distinguish between HIV-1 positive/AIDS patients on antiretroviral treatment and HIV-1 negative individuals [J].

Hewer, R. ;

Vorster, J. ;

Steffens, F. E. ;

Meyer, D. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 41 (04) :1442-1446

[3] Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning [J].

Kenny, Louise C. ;

Dunn, Warwick B. ;

Ellis, David I. ;

Myers, Jenny ;

Baker, Philip N. ;

Kell, Douglas B. .

METABOLOMICS, 2005, 1 (03) :227-234

[4]

Metabolomics and systems biology: making sense of the soup[J] . Douglas B Kell.Current Opinion in Microbiology . 2004 (3)

[5]

Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis[J] . John C. Lindon,Elaine Holmes,Mary E. Bollard,Elizabeth G. Stanley,Jeremy K. Nicholson.Biomarkers . 2004 (1)

[6]

Parallel analysis of transcript and metabolic profiles: a new approach in systems biology[J] . Ewa Urbanczyk‐Wochniak,Alexander Luedemann,Joachim Kopka,Joachim Selbig,Ute Roessner‐Tunali,Lothar Willmitzer,Alisdair R Fernie.EMBO reports . 2003 (10)

[7]

Chemical diagnosis of Lesch–Nyhan syndrome using gas chromatography-mass spectrometry detection[J] . Chie Ohdoi,William L. Nyhan,Tomiko Kuhara.Journal of Chromatography B . 2003 (1)

[8] Metabolomics – the link between genotypes and phenotypes [J].

Oliver Fiehn .

Plant Molecular Biology, 2002, 48 :155-171

[9]

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J] . J. K. Nicholson,J. C. Lindon,E. Holmes.Xenobiotica . 1999 (11)

← 1 →