晚期糖基化终末产物致动脉粥样硬化的机制

被引:9
作者
蒲里津
陆林
沈卫峰
机构
[1] 上海交通大学医学院附属瑞金医院心内科
关键词
晚期糖基化终末产物; 动脉粥样硬化; 内皮细胞;
D O I
暂无
中图分类号
R587.2 [糖尿病性昏迷及其他并发症];
学科分类号
摘要
晚期糖基化终末产物(advanced glycation end products,AGE)是由还原糖的羰基与游离氨基反应形成的复合物。AGE通过与其受体(RAGE)结合,改变细胞内信号转导、诱导炎症、增强氧化应激;与胶原交联、修饰脂蛋白等损害血管的完整性;这些导致血管内皮细胞功能紊乱,刺激平滑肌细胞迁移增殖,启动及加速糖尿病动脉粥样硬化和血管并发症的发生发展。阻断AGE-RAGE系统对防治糖尿病并发症具有重要意义。
引用
收藏
页码:98 / 100
页数:3
相关论文
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