老年患者冠状动脉搭桥术后血清NSE和S-100β蛋白水平的变化

被引：6

作者：

张挺杰

王祥瑞

杭燕南

机构：

[1] 上海第二医科大学附属仁济医院麻醉科

来源：

临床麻醉学杂志 | 2004年 / 12期

关键词：

老年; 心肺转流; 冠状动脉分流术; 磷酸烯醇丙酮酸化酶; S100蛋白;

D O I：

暂无

中图分类号：

R654.2 [心脏];

学科分类号：

1002 ; 100210 ;

摘要：

目的　观察老年患者心肺转流 (CPB)冠状动脉搭桥术 (CABG)后血清神经元特异性烯醇化酶 (NSE)及S 10 0 β蛋白水平变化 ,探讨其与术后神经精神并发症的关系。方法　年龄≥ 6 5岁择期CABG患者 30例 ,于术前、术终、术后 12、2 4及 4 8h五个时间点测定血清NSE和S 10 0 β蛋白水平。评估术后急性精神障碍和脑血管意外发生情况。结果　 (1)血清NSE水平在术终、术后 12h及2 4h显著升高 ,血清S 10 0 β蛋白水平仅在术终显著升高 ;(2 )术后发生急性精神障碍患者术终、术后12h血清NSE、S 10 0 β蛋白水平显著高于未发生者 ;(3)术前合并糖尿病者血清NSE水平在术终、术后 12、2 4h及S 10 0 β蛋白水平在术终显著高于非糖尿病患者。结论　 (1)老年患者CABG后血清NSE和S 10 0 β蛋白水平明显升高 ;(2 )术后血清NSE和S 10 0 β蛋白水平升高与术后急性精神障碍有关 ;(3)术前合并糖尿病是CABG后脑损伤和精神障碍的危险因素

引用

页码：707 / 709

页数：3

共 8 条

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