精神分裂症患者失匹性负波(MMN)研究

被引：7

作者：

楼翡璎

陈兴时

张明岛

梁建华

陈冲

机构：

[1] 上海市精神卫生研究所

来源：

现代电生理学杂志 | 2006年 / 03期

关键词：

精神分裂症; 失匹性负波; 认知障碍; 随访研究; 状态标志;

D O I：

暂无

中图分类号：

R749.3 [精神分裂症];

学科分类号：

100205 ;

摘要：

目的:了解首发精神分裂症患者失匹性负波(MMN)的特征以及治疗缓解后MMN的变化。方法:应用美国Bravo脑电生理仪,记录45例首发精神分裂症患者和40名健康人的MMN,同时记录P300电位比较,并用阳性和阴性症状量表(PANSS)评定患者精神症状。患者组于治疗5周和12周时进行MMN随访。结果:(1)与正常组比较,首发精神分裂症组的MMN潜伏期延迟和波幅降低(正常组199·7±29·9ms和7·8±3·8μV,患者组221·4±32·6ms,4·5±3·3μV,P均<0·01),患者组P300中靶潜伏期P3同时延迟(P<0·01)。(2)MMN潜伏期延长和波幅低,与PANSS阳性症状和思维障碍分呈负相关(P<0·05～0·01)。(3)患者组经治疗12周后,MMN波幅呈增大改变和潜伏期缩短(P<0·01),反映患者的认知功能改善。结论:MMN技术可反映首发精神分裂症患者诱发脑电的自动加工过程。MMN可作为精神分裂症患者的临床应用检测指标。

引用

页码：131 / 134

页数：4

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