中药有效成分及其配伍对实验性类风湿关节炎治疗作用的研究进展

被引：9

作者：

马琳 ^{[1
]}

刘维 ^{[2
]}

机构：

[1] 天津中医药大学研究生院

[2] 天津中医药大学第一附属医院

来源：

辽宁中医杂志 | 2015年 / 42卷 / 11期

基金：

高等学校博士学科点专项科研基金;

关键词：

类风湿关节炎; 中药有效成分; 配伍; 胶原诱导性关节炎;

D O I：

10.13192/j.issn.1000-1719.2015.11.081

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

类风湿关节炎(RA)是一种全身性自身免疫性疾病,为难治性疾病之一,中药及其有效成分治疗RA具有疗效确切、不良反应少的优势,近年来,国内外针对中药有效成分及有效成分配伍抗RA进行了大量的实验和临床研究工作,很多中药的活性成分及其作用机制逐步阐明,开发出以青藤碱注射液、雷公藤多苷片和白芍总苷片为主的靶点明确、疗效确切的中药治疗药物,具有良好的应用发展前景。动物模型在认识RA的病因和发病机制中起重要作用,在多种评价抗RA药物作用的动物模型中,作者认为应用Ⅱ型胶原蛋白混合弗氏佐剂诱导的胶原诱导性关节炎(collagen-induced arthritis,CIA)模型是目前公认的筛选和研究治疗RA药物的理想模型。故文章对中药有效成分治疗以CIA为代表的RA实验模型的基础研究进展进行综合评述,并对研究中存在的问题和今后的发展趋势进行探讨。

引用

页码：2265 / 2268

页数：4

共 53 条

[1]

雷公藤多苷联合人参皂苷对胶原诱导关节炎大鼠CD4+CD25+Foxp3+调节性T细胞的影响及骨免疫学机制探讨 [D].

张秋媛 .

河北医科大学,

2012

[2]

Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis.[J].Yan Shi;Siamak Sandoghchian Shotorbani;Zhaoliang Su;Yanfang Liu;Jia Tong;Dong Zheng;Jianguo Chen;Yingzhao Liu;Yan Xu;Zhijun Jiao;Shengjun Wang;Liwei Lu;Xinxiang Huang;Huaxi Xu;Zoltan Szekanecz.Clinical and Developmental Immunology.2011,

[3]

Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis [J].

Chao, Cheng-Chi ;

Chen, Shi-Juan ;

Adamopoulos, Iannis E. ;

Davis, Nicole ;

Hong, Kyu ;

Vu, Anna ;

Kwan, Sylvia ;

Fayadat-Dilman, Laurence ;

Asio, Agelio ;

Bowman, Edward P. .

AUTOIMMUNITY, 2011, 44 (03) :243-252

[4]

Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model [J].

Moon, Dong-Oh ;

Kim, Mun-Ok ;

Choi, Yung Hyun ;

Park, Yung-Min ;

Kim, Gi-Young .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2010, 10 (05) :605-610

[5]

Soluble receptor for advanced glycation end products triggers a proinflammatory cytokine cascade via β2 integrin Mac‐1.[J].Rille Pullerits;Mikael Brisslert;Ing‐Marie Jonsson;Andrej Tarkowski.Arthritis & Rheumatism.2006, 12

[6]

Triptolide; a diterpenoid triepoxide; suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.[J].Na Lin;Chunfang Liu;Cheng Xiao;Hongwei Jia;Keisuke Imada;Hao Wu;Akira Ito.Biochemical Pharmacology.2006, 1

[7]

The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis.[J].Jing Zhou;Cheng Xiao;Linhua Zhao;Hongwei Jia;Ning Zhao;Cheng Lu;Dajian Yang;Johnny Cheuk-on Tang;Albert S.C. Chan;Ai-ping Lu.International Immunopharmacology.2005, 2

[8]

Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription [J].

Wang, B ;

Ma, L ;

Tao, X ;

Lipsky, PE .

ARTHRITIS AND RHEUMATISM, 2004, 50 (09) :2995-3003

[9]

Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-κB and c-Jun NH2-terminal kinase [J].

Kim, YH ;

Lee, SH ;

Lee, JY ;

Choi, SW ;

Park, JW ;

Kwon, TK .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 494 (01) :1-9

[10]

Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes.[J].Abdelhamid Liacini;Judith Sylvester;Muhammad Zafarullah.Biochemical and Biophysical Research Communications.2004, 1

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