水通道蛋白与脑

被引:3
作者
鲁宏
机构
[1] 重庆医科大学基础医学院解剖学教研室重庆
关键词
水通道蛋白; 脑; 水代谢;
D O I
暂无
中图分类号
R338 [神经生理学];
学科分类号
0710 ; 071006 ;
摘要
在哺乳动物内已发现有十种水通道蛋白 (AQP0~AQP9)分布于水代谢活跃的器官。每种水通道蛋白都具有组织分布特异性 ,不同水通道蛋白之间的结构相似 ,均以四聚体形式存在 ,每一单体构成一个功能单位 (水通道 ) ,具有转运水的功能。脑组织中的水通道蛋白主要为AQP4和AQP1 ,其分子结构与功能在基因水平存在动态调节。深入研究它们在脑内的分布与功能 ,尤其与脑水肿之间的关系 ,对指导脑水肿治疗和开发新药均具有重要意义
引用
收藏
页码:621 / 622
页数:2
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