乳腺癌组织Survivin表达与细胞增殖的关系

被引：7

作者：

桑占发 ^{[1
]}

王兴 ^{[2
]}

齐玉新 ^{[1
]}

赵国清 ^{[1
]}

机构：

[1] 中国人民解放军第医院病理科

[2] 中国人民解放军第医院医务处

来源：

现代肿瘤医学 | 2009年 / 17卷 / 08期

关键词：

乳腺癌; Survivin; Ki-67; 增殖指数;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

100214 ;

摘要：

目的:探讨乳腺癌组织中Survivin表达的临床病理学意义及其与癌细胞增殖的关系。方法:应用免疫组织化学SP法检测Survivin、Ki-67蛋白在96例乳腺癌组织中及20例正常乳腺组织的表达,分析Survivin表达与Ki-67增殖指数及各临床病理因素的关系。结果:Survivin阳性表达乳腺癌的Ki-67增殖指数(35.32±21.28%)明显高于Survivin阴性者(20.42±11.34%),Survivin表达与肿瘤细胞增殖呈正相关(P<0.01);Survivin在乳腺癌组织中的表达率为70.83%(68/96),正常乳腺组织未见Survivin表达;Survivin蛋白的表达与临床分期、淋巴结转移和5年生存率有关(P<0.05),与年龄、是否绝经、肿瘤大小和组织学分级均无关。结论:Survivin不仅参与凋亡的调控,还促进细胞增殖。Survivin蛋白在乳腺癌中表达上调,提示其通过抑制凋亡在乳腺癌发生、发展中起重要作用,过度表达提示预后不良。

引用

页码：1478 / 1481

页数：4

共 16 条

[1]

Expression of survivin, platelet-derived growth factor A (PDGF-A) and PDGF receptor α in primary central nervous system lymphoma[J] . K. Karabatsou,P. Pal,S. Dodd,B. Haylock,M. Aguirreburualde,N. Moxam,W. Pinson-Ellis,J. Broome,N.G. Rainov. &nbspJournal of Neuro-Oncology . 2006 (2)

[2]

High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer[J] . Paul N. Span,Vivianne C.G. Tjan-Heijnen,Peggy Manders,Doorlene Tienoven,Jeffrey Lehr,Fred C.G.J. Sweep. &nbspBreast Cancer Research and Treatment . 2006 (2)

[3]

Detection of Survivin -expressing circulating cancer cells in the peripheral blood of breast cancer patients by a RT-PCR ELISA[J] . Shang-Mian Yie,Bie Luo,Nai-Yao Ye,Ke Xie,Shang-Rong Ye. &nbspClinical & Experimental Metastasis . 2006 (5)

[4]

乳腺癌组织中survivin,p53蛋白的表达与预后的关系[J]. 毛杰,海健,舒衡平,唐利立,申正堂,邬玉辉,欧慧英. 中国普通外科杂志. 2005(04)

[5] Relationship between survivin expression and recurrence,and prognosis in hepatocellular carcinoma [J].

Chao-Ping Ye Cheng-Zhi Qiu Wei Zhuang Xin-Feng Li Department of Hepatobiliary Surgery .

World Journal of Gastroenterology, 2007, (46) :6264-6268

[6]

Expression of survivin and its clinico-pathological correlations in invasive ductal carcinoma of the breast. Al-Joudi F S,Iskandar Z A,Hasnan J,et al. Singapore Med . 2007

[7]

Proliferation, apoptosis, and survivin expression in keratinocytic neoplasms and hyperplasias. Bowen AR,Hanks AN,Murphy KJ,et al. American Journal of Dermatopathology . 2004

[8]

Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer. Yip KW,Shi W,Pintilie M,et al. Clinical Cancer Research . 2006

[9]

Disparitiesin breast cancer treatment and survival for women withdisabilities. McCarthy EP,Ngo LH,Roetzheim RG,et al. Annals of Internal Medicine . 2006

[10]

Prognostic importance of survivin in breast cancer. Kennedy S M,O’Driscoll I,Purcell R,et al. British Journal of Cancer . 2003

← 1 2 →