γ-氨基丁酸及其受体与肿瘤增殖和侵袭的关系

被引：10

作者：

缪宇锋 ^{[1
]}

汪芳裕 ^{[2
]}

陈龙邦 ^{[3
]}

机构：

[1] 南京大学医学院临床学院

[2] 南京军区南京总医院消化内科

[3] 南京军区南京总医院肿瘤科

来源：

中国肿瘤生物治疗杂志 | 2009年 / 16卷 / 01期

关键词：

γ-氨基丁酸; γ-氨基丁酸受体; 肿瘤; 增殖; 侵袭;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

γ-氨基丁酸(γ-aminobutyric acid,GABA)是一种哺乳动物中枢神经系统重要的抑制性神经递质,GABA通过与不同类型的GABA受体(GABA receptor,GABAR)结合对机体多种功能发挥特异性调节作用。近年来研究发现,GABA与GA-BAR还广泛存在于外周组织,参与细胞间的信息传递,与细胞的分化和成熟密切相关。此外,GABA及其受体还可通过特定的信号转导通路影响某些肿瘤的增殖和侵袭转移等恶性潜能。某些肿瘤伴随GABA及其受体的高表达,阻断GABAR信号则可抑制肿瘤细胞的增殖。GABA与GABAR结合后可通过上调MMP表达、提高胞内钙离子浓度、活化MAPK激酶链等途径促进肿瘤的侵袭和转移。随着研究的深入,GABA及其受体信号通路蛋白分子有可能成为肿瘤诊断与治疗的潜在靶点。

引用

页码：93 / 96

页数：4

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