阿片类药物诱导痛觉过敏的研究进展

被引：27

作者：

王小慧

王俊

机构：

[1] 中国医科大学附属第一医院麻醉科

来源：

实用药物与临床 | 2011年 / 14卷 / 05期

关键词：

痛觉过敏; 阿片类药物; 药物耐受;

D O I：

10.14053/j.cnki.ppcr.2011.05.032

中图分类号：

R971 [神经系统药物];

学科分类号：

100115 [医学神经生物学];

摘要：

阿片类药物能促使中枢敏化及诱导痛觉过敏,称为阿片类药物诱导的痛觉过敏(Opioid-inducedhyperalgesia,OIH),此现象已经被大量临床观察和基础研究所证实。近年来,关于OIH产生机制的研究正在成为麻醉和疼痛治疗领域的热点。目前,关于OIH产生机制的研究主要集中在中枢谷氨酰能系统活性增强、内源性神经肽的作用、脊髓下行易化作用等方面。本文就OIH的发生机制、评估与治疗等方面的进展进行综述。

引用

页码：419 / 423

页数：5

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