丁苯酞对慢性低灌注后神经血管单元的保护作用

被引：8

作者：

魏微

徐琴

黄勇华

机构：

[1] 北京军区总医院神经内科

来源：

中国动脉硬化杂志 | 2014年 / 22卷 / 10期

关键词：

慢性低灌注; 丁苯酞; 神经血管单元;

D O I：

10.20039/j.cnki.1007-3949.2014.10.008

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

目的研究丁苯酞对慢性低灌注后神经血管单元是否有保护作用。方法雄性Wistar大鼠48只随机分为假手术组、缺血模型组和丁苯酞组。缺血模型组与丁苯酞组大鼠结扎双侧颈总动脉。电镜观察神经血管单元的超微结构改变。结果与缺血模型组相比,丁苯酞组低灌注后血管内皮细胞周围肿胀减轻,神经元线粒体嵴断裂程度减轻,神经血管单元微环境较好。结论丁苯酞对慢性低灌注后神经血管单元有保护作用。

引用

页码：1015 / 1018

页数：4

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