精神分裂症异质性及其中枢五羟色胺功能研究

被引：15

作者：

金卫东

臧德馨

曹明莉

孙敬烈

唐珞珈

机构：

[1] 湖北医学院附属一院精神科

[2] 武汉大学分测试中心

来源：

中国神经精神疾病杂志 | 1993年 / 03期

关键词：

精神分裂症; 色氨酸; 五羧色胺; 五羟吲哚乙酸; 异质性;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

本文应用高效液相色谱(HPLC)对67例精神分裂症及10例健康对照组脑脊液中色氨酸(TRP)、五羟色胺(5-HT)、五羟吲哚乙酸(5-HIAA)进行测试,同时引入5-HT相对代谢率概念用5-HIAA/5-HT表示,并以Andreasen分型标准划分42例阳性精神分裂症和25例阴性精神分裂症。结果发现,精神分裂症患者脑脊液中TRP明显低于正常对照组,阳性(Ⅰ型)分裂症5-HIAA以及5-HIAA/5-HT明显低于阴性(Ⅱ型)精神分裂症,并对精神分裂症的5-HT代谢障碍假说及其异质性进行了讨论。

引用

页码：157 / 159+192 +192

页数：4

共 14 条

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