腰椎间盘突出发病机制的研究进展

被引：205

作者：

玉超杰

楚野

梁斌

机构：

[1] 广西壮族自治区人民医院骨科

来源：

中国临床新医学 | 2017年 / 10卷 / 08期

关键词：

腰椎间盘突出; 发病机制; 脊柱关节病;

D O I：

暂无

中图分类号：

R681.53 [];

学科分类号：

摘要：

腰椎间盘突出是骨科的常见病、多发病之一,通常引起慢性腰痛、下肢麻痛等症状及相应体征,严重困扰患者的生活。随着现在人们生活作业方式的变化,腰椎间盘突出的患者逐年增加,尤其是年轻患者的数量不断递增。虽然关于其发病机制的研究一直以来从未停止,但因其复杂的生理病理改变,导致发病机制还未有明确而统一的解释。而关于其在各个领域的研究已经取得瞩目的成果,如机械力学、基质金属蛋白酶、免疫炎症反应等各类学说。该文就其发病机制综合国内外文献进行综述,为当今的发展方向提供新的引导。

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页码：824 / 828

页数：5

相关论文

共 26 条

[1]

Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration [J].

Bachmeier, Beatrice E. ;

Nerlich, Andreas ;

Mittermaier, Norbert ;

Weiler, Christoph ;

Lumenta, Christianto ;

Wuertz, Karin ;

Boos, Norbert .

EUROPEAN SPINE JOURNAL, 2009, 18 (11) :1573-1586

[2]

What is intervertebral disc degeneration, and what causes it? [J].

Adams, Michael A. ;

Roughley, Peter J. .

SPINE, 2006, 31 (18) :2151-2161

[3]

Differential regulation of matrix degrading enzymes in a TNFα-induced model of nucleus pulposus tissue degeneration [J].

Seguin, Cheryle A. ;

Bojarski, Marla ;

Pilliar, Robert M. ;

Roughley, Peter J. ;

Kandel, Rita A. .

MATRIX BIOLOGY, 2006, 25 (07) :409-418

[4]

Tumor necrosis factorα modulates matrix production and catabolism in nucleus pulposus tissue [J].

Séguin, CA ;

Pilliar, RM ;

Roughley, PJ ;

Kandel, RA .

SPINE, 2005, 30 (17) :1940-1948

[5]

Biology of intervertebral disc aging and degeneration - Involvement of the extracellular matrix [J].

Roughley, PJ .

SPINE, 2004, 29 (23) :2691-2699

[6]

Human nucleus pulposis can respond to a pro-inflammatory stimulus [J].

Burke, JG ;

Watson, RWG ;

Conhyea, D ;

McCormack, D ;

Dowling, FE ;

Walsh, MG ;

Fitzpatrick, JM .

SPINE, 2003, 28 (24) :2685-2693

[7]

New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration [J].

Kroeber, MW ;

Unglaub, F ;

Wang, HL ;

Schmid, C ;

Thomsen, M ;

Nerlich, A ;

Richter, W .

SPINE, 2002, 27 (23) :2684-2690

[8]

Comparative gene expression profiling of normal and degenerative discs - Analysis of a rabbit annular laceration model [J].

Anderson, DG ;

Izzo, MW ;

Hall, DJ ;

Vaccaro, AR ;

Hilibrand, A ;

Arnold, W ;

Tuan, RS ;

Albert, TJ .

SPINE, 2002, 27 (12) :1291-1296

[9]

Matrix metalloproteinases and aggrecanase - Their role in disorders of the human intervertebral disc [J].

Roberts, S ;

Caterson, B ;

Menage, J ;

Evans, EH ;

Jaffray, DC ;

Eisenstein, SM .

SPINE, 2000, 25 (23) :3005-3013

[10]

Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading [J].

Lotz, JC ;

Chin, JR .

SPINE, 2000, 25 (12) :1477-1482