代谢性核受体与糖尿病肾病

被引：5

作者：

魏元怡

张晓燕

管又飞

机构：

[1] 大连医科大学医学科学研究院

来源：

科技导报 | 2016年 / 34卷 / 20期

关键词：

糖尿病肾病; 代谢性核受体; 过氧化物酶体增殖物激活受体; 肝X受体; 法尼酯X受体;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R692.9 [其他疾病];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

随着中国糖尿病发病率逐年提高,糖尿病肾病已成为终末期肾病第二大原因,但其发病机制仍未阐明。代谢性核受体在调节糖脂代谢方面发挥重要作用,也发现其与肾脏功能调节有关,其激动剂可能成为治疗糖尿病肾病的新药。本文综述了3类代谢性核受体——PPARs、LXRs和FXRs对肾脏的保护作用及其机制,讨论了代谢性核受体作为糖尿病肾病潜在治疗靶点在糖尿病肾病防治中的重要意义。

引用

页码：45 / 50

页数：6

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