阿托伐他汀对进展性脑卒中治疗作用的探讨

被引：13

作者：

季辉 ^{[1
]}

李俐涛 ^{[2
]}

温雅 ^{[1
]}

苗江永 ^{[1
]}

祝春华 ^{[1
]}

牛小芸 ^{[3
]}

张祥建 ^{[1
]}

机构：

[1] 河北医科大学第二医院神经内科

[2] 河北省人民医院神经内科

[3] 北京嘉林药业股份有限公司

来源：

脑与神经疾病杂志 | 2013年 / 21卷 / 06期

关键词：

进展性脑卒中; 阿托伐他汀; 疗效;

D O I：

暂无

中图分类号：

R743.32 [脑血栓形成];

学科分类号：

1002 ;

摘要：

目的探讨他汀类药物对进展性脑卒中的治疗作用。方法对发病在48 h内的105例进展性脑卒中患者临床资料进行研究。入选病例分为他汀治疗组及对照组:对照组47例采用常规治疗,未予阿托伐他汀治疗;他汀治疗组58例,在常规治疗基础上,每晚睡前口服阿托伐他汀钙20 mg·d-1。两组患者治疗前和治疗后14d采用NIHSS评分评价神经功能缺损情况。结果他汀治疗组NIHSS评分改善显著优于对照组(P<0.0 5)。结论他汀类药物可提高进展性脑卒中患者的疗效。

引用

页码：404 / 406

页数：3

共 12 条

[1]

神经病学.[M].王维治主编;.人民卫生出版社.2004,

[2] Ultra-Sensitive Molecular MRI of Vascular Cell Adhesion Molecule-1 Reveals a Dynamic Inflammatory Penumbra After Strokes [J].

Gauberti, Maxime ;

Montagne, Axel ;

Marcos-Contreras, Oscar A. ;

Le Behot, Audrey ;

Maubert, Eric ;

Vivien, Denis .

STROKE, 2013, 44 (07) :1988-+

[3]

Risk prediction of very early recurrence; death and progression after acute ischaemic stroke.[J].I. L. Maier;M. Bauerle;P. Kermer;H.‐J. Helms;T. Buettner.Eur J Neurol.2012, 4

[4]

Atorvastatin inhibits the inflammatory response caused by anti-M3 peptide IgG in patients with primary Sj?gren’s syndrome.[J].Silvia Reina;Daniela Passafaro;Leonor Sterin-Borda;Enri Borda.Inflammopharmacology.2012, 5

[5] Short-Term Effect of Atorvastatin on Carotid Artery Elasticity A Pilot Study [J].

Ratchford, Elizabeth V. ;

Gutierrez, Jose ;

Lorenzo, Dalia ;

McClendon, Mark S. ;

Della-Morte, David ;

DeRosa, Janet T. ;

Elkind, Mitchell S. V. ;

Sacco, Ralph L. ;

Rundek, Tatjana .

STROKE, 2011, 42 (12) :3460-3464

[6] Association between Inflammatory Biomarkers and Progression of Intracranial Large Artery Stenosis after Ischemic Stroke [J].

Shimizu, Kanako ;

Shimomura, Kana ;

Tokuyama, Yoshiaki ;

Sakurai, Kenzo ;

Isahaya, Kenji ;

Takaishi, Satoshi ;

Kato, Bunta ;

Usuki, Noriko ;

Shimizu, Takahiro ;

Yamada, Koji ;

Hasegawa, Yasuhiro .

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2013, 22 (03) :211-217

[7]

Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: Down-regulated 12/15-LOX; p38MAPK and cPLA2 expression; ameliorated BBB permeability.[J].Lili Cui;Xiangjian Zhang;Rui Yang;Lina Wang;Lingling Liu;Min Li;Wei Du.Brain Research.2010,

[8] Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-κB expression [J].

Wang, Lina ;

Zhang, Xiangjian ;

Liu, Lingling ;

Yang, Rui ;

Cui, Lili ;

Li, Min .

NEUROSCIENCE LETTERS, 2010, 471 (03) :152-156

[9]

Curcumin upregulates transcription factor Nrf2; HO-1 expression and protects rat brains against focal ischemia.[J].Chenhui Yang;Xiangjian Zhang;Hongguang Fan;Ying Liu.Brain Research.2009,

[10]

Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-κB expression.[J].Ying Liu;Xiang-jian Zhang;Chen-hui Yang;Hong-guang Fan.Brain Research.2009,

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