内质网应激与缺血再灌注损伤及其防护

被引:28
作者
祝筱梅
刘秀华
机构
[1] 中国人民解放军总医院病理生理研究室
关键词
内质网应激; 缺血/再灌注; 缺血预处理;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100104 ;
摘要
内质网应激(ERS)是细胞内一种适应性保护机制,但持续存在或过强时则最终诱导细胞凋亡,造成组织损伤。缺血/再灌注(I/R)时ATP耗竭、钙超载及大量自由基生成等因素诱导过度ERS导致组织损伤。缺血预处理可激发适当的ERS,增强细胞耐受后续长时间缺血刺激的能力,延缓或减轻I/R造成的组织损伤。
引用
收藏
页码:177 / 180+184 +184
页数:5
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