甲状腺髓样癌靶向治疗新进展

被引：8

作者：

柴红

陈泽泉

余永利

机构：

[1] 上海交通大学附属第六人民医院核医学科

来源：

上海交通大学学报(医学版) | 2011年 / 31卷 / 10期

关键词：

甲状腺髓样癌; 靶向治疗; 信号通路;

D O I：

暂无

中图分类号：

R736.1 [甲状腺肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

对于晚期手术无法完整切除,且常规放化疗无效的甲状腺髓样癌(MTC)通常缺乏有效地治疗手段。靶向治疗是近年来在治疗血液和实体肿瘤中涌现出的新的治疗手段。随着对肿瘤发生、发展和转移的分子生物学机制深入,这种治疗手段也被用于MTC的治疗研究。目前用于MTC的主要药物包括小分子多靶点酪氨酸激酶抑制剂、血管内皮生长因子受体抑制剂和放射性核素靶向治疗药物,这些药物在基础研究、动物实验和临床实用研究中获得令人鼓舞的结果。其他药物如内皮生长因子受体(EGFR)酪氨酸激酶抑制剂吉非替尼(Gefitinib,ZD1839)、吲哚美辛和17烯丙胺17脱甲氧格尔徳霉素(17-AAG)等,在治疗晚期甲状腺髓样癌的临床试验中也显示出良好的前景。

引用

页码：1470 / 1474

页数：5

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