5-羟色胺与疼痛

被引：17

作者：

黄建国 ^{[1
,2
]}

黄朝頔 ^{[3
]}

龚启英 ^{[4
,2
]}

李桂明 ^{[5
]}

机构：

[1] 南方医科大学附属花都医院皮肤科

[2] 广州市花都区人民医院

[3] 遵义医学院珠海校区临床医学

[4] 南方医科大学附属花都医院血液内科

[5] 重庆医科大学第一医院皮肤科

来源：

中国皮肤性病学杂志 | 2015年 / 29卷 / 09期

关键词：

5-羟色胺; 疼痛;

D O I：

10.13735/j.cjdv.1001-7089.201409020

中图分类号：

R751 [皮肤病学];

学科分类号：

100227 [皮肤病学];

摘要：

疼痛是一些皮肤病常见的临床表现,疼痛的发病机制尚不完全明确。5-羟色胺(5-HT),5-HT转运体与疼痛高度相关。5-HT(7)受体介导疼痛具有特异性。5-HT和5-HT(2A)受体参与神经病理性疼痛的维护是通过上调CGRP-IR(降钙素基因相关肽免疫反应活性)的表达进行的,应用酮色林(5-HT(2A)受体拮抗剂)是治疗神经病理性疼痛的一种有前途的治疗方法;曲坦类药物[5-HT(1B和1D)受体激动剂]已被证明能有效的治疗疼痛;氟西汀(5-HT再摄取抑制剂)可能会产生好的癌症疼痛控制和减轻耐受性的发展,因而研究5-HT与疼痛的关系为开发5-HT类新药,为治疗疼痛取得好效果具有重要的意义。

引用

页码：974 / 977

页数：4

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