内毒素致急性肺损伤的发病机制研究进展

被引：23

作者：

赵利利

戎浩

孙芳云

机构：

[1] 西藏民族学院医学院生命科学基础研究实验室

来源：

实用药物与临床 | 2015年 / 18卷 / 04期

关键词：

肺损伤; 内毒素; 发病机制; 脂多糖;

D O I：

10.14053/j.cnki.ppcr.201504026

中图分类号：

R563.8 [呼吸衰竭];

学科分类号：

100201 [内科学];

摘要：

急性肺损伤(Acute lung injury,ALI)是由肺内外各种致伤因素引起的症状严重、发展快、病死率高的临床危重症,由内毒素引起的急性肺损伤最为常见。因此对于内毒素引起的急性肺损伤的发病机制的研究极其重要。本文就近年来国内外期刊对内毒素致急性肺损伤的发病机制进行初步论述,为进一步研究内毒素性急性肺损伤提供依据。

引用

页码：466 / 469

页数：4

共 10 条

[1]

Trypsin inhibits lipopolysaccharide signaling in macrophages via toll-like receptor 4 accessory molecules [J].

Komatsu, Hiroyuki ;

Shimose, Akihiro ;

Shimizu, Takashi ;

Mukai, Yu ;

Kobayashi, Jun ;

Ohama, Takashi ;

Sato, Koichi .

LIFE SCIENCES, 2012, 91 (3-4) :143-150

[2]

Sevoflurane reduces severity of acute lung injury possibly by impairing formation of alveolar oedema [J].

Schlaepfer, M. ;

Leutert, A. C. ;

Voigtsberger, S. ;

Lachmann, R. A. ;

Booy, C. ;

Beck-Schimmer, B. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2012, 168 (01) :125-134

[3]

Protective effect of erythropoietin on myocardial infarction in rats by inhibition of caspase-12 expression [J].

Weng, Shaoxiang ;

Zhu, Xiaoqing ;

Jin, Yue ;

Wang, Ting ;

Huang, He .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2011, 2 (05) :833-836

[4]

Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity.[J].Sarah L. Doyle;Luke A.J. O’Neill.Biochemical Pharmacology.2006, 9

[5]

Halogenated Anesthetics reduce interleukin-1 β-induced cytokine secretion by rat alveolar type II cells in primary culture [J].

Giraud, O ;

Molliex, S ;

Rolland, C ;

Leçon-Malas, V ;

Desmonts, JM ;

Aubier, M ;

Dehoux, M .

ANESTHESIOLOGY, 2003, 98 (01) :74-81

[6]

Inhibition of p38 MAPK Activation via Induction of MKP-1: Atrial Natriuretic Peptide Reduces TNF-α–Induced Actin Polymerization and Endothelial Permeability.[J].Alexandra K. Kiemer;Nina C. Weber;Robert Fürst;Nicole Bildner;Stefanie Kulhanek-Heinze;Angelika M. Vollmar.Circulation Research: Journal of the American Heart Association.2002, 8

[7]

内质网应激在大鼠急性肺损伤中的意义 [J].