肥胖与骨质疏松症关系的研究进展

被引：33

作者：

鲍晓雪

王娜

李玉坤

机构：

[1] 河北医科大学第三医院内分泌二科河北省骨科生物力学重点实验室

来源：

中华临床医师杂志(电子版) | 2015年 / 9卷 / 14期

关键词：

肥胖症; 骨质疏松; 脂肪因子类; 促炎细胞因子;

D O I：

暂无

中图分类号：

R589.2 [脂肪代谢障碍]; R580 [];

学科分类号：

100201 [内科学];

摘要：

肥胖是许多慢性疾病的危险因素。肥胖与骨之间的病理生理关系是复杂的,最近来自流行病学和动物研究的数据表明:脂肪堆积对骨密度不利。肥胖可能通过多种机制影响骨代谢,由于脂肪细胞和成骨细胞起源于共同的多能间充质干细胞,肥胖能增强脂肪细胞分化并促进脂肪积累,进而减少成骨细胞分化和骨形成。肥胖与慢性炎症有关,在肥胖患者中,循环血液和组织的促炎细胞因子水平增加,从而通过修饰NF-κB(RANK)/RANKL/骨保护通路的受体活性,而增进破骨细胞活性并加速骨吸收。此外,肥胖患者中脂肪细胞分泌瘦素过多和(或)脂联素生成过少可能直接影响骨形成或通过上调促炎细胞因子而间接影响骨吸收。另外,高脂摄入可能干预肠道钙吸收而降低成骨可利用的钙量。本篇叙述了肥胖对骨代谢影响的作用机制,阐明脂肪和骨代谢之间在分子水平的关系,有助于开发预防或治疗肥胖和骨质疏松的治疗性药剂。

引用

页码：2749 / 2753

页数：5

共 18 条

[1]

Relationships between serum adipocyte hormones (adiponectin, leptin, resistin), bone mineral density and bone metabolic markers in osteoporosis patients [J].

Mohiti-Ardekani, J. ;

Soleymani-Salehabadi, H. ;

Owlia, M. B. ;

Mohiti, A. .

JOURNAL OF BONE AND MINERAL METABOLISM, 2014, 32 (04) :400-404

[2]

Fat and Bone Interactions [J].

Bermeo, Sandra ;

Gunaratnam, Krishanthi ;

Duque, Gustavo .

CURRENT OSTEOPOROSIS REPORTS, 2014, 12 (02) :235-242

[3]

Obesity: Friend or foe for osteoporosis.[J].Sudhaa Sharma;Vishal Tandon;Shagun Mahajan;Vivek Mahajan;Annil Mahajan.Journal of Mid-life Health.2014, 1

[4]

The impact of bone marrow adipocytes on osteoblast and osteoclast differentiation [J].

Muruganandan, Shanmugam ;

Sinal, Christopher J. .

IUBMB LIFE, 2014, 66 (03) :147-155

[5]

Association of polymorphisms in the leptin and leptin receptor genes with inflammatory mediators in patients with osteoporosis [J].

Ye, Xing L. ;

Lu, Chun F. .

ENDOCRINE, 2013, 44 (02) :481-488

[6]

Abdominal Fat Is Associated With Lower Bone Formation and Inferior Bone Quality in Healthy Premenopausal Women: A Transiliac Bone Biopsy Study [J].

Cohen, Adi ;

Dempster, David W. ;

Recker, Robert R. ;

Lappe, Joan M. ;

Zhou, Hua ;

Zwahlen, Alexander ;

Mueller, Ralph ;

Zhao, Binsheng ;

Guo, Xiaotao ;

Lang, Thomas ;

Saeed, Isra ;

Liu, X. Sherry ;

Guo, X. Edward ;

Cremers, Serge ;

Rosen, Clifford J. ;

Stein, Emily M. ;

Nickolas, Thomas L. ;

McMahon, Donald J. ;

Young, Polly ;

Shane, Elizabeth .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (06) :2562-2572

[7]

IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women.[J].Miriam A. Bredella;Pouneh K. Fazeli;Beata Lecka-Czernik;Clifford J. Rosen;Anne Klibanski.Bone.2013, 2

[8]

Childhood Obesity Is Associated With Increased Risk of Most Lower Extremity Fractures [J].