双酚A的毒性作用机制

被引:20
作者
纪红蕊
陈家驹
张茜
邹凤娟
李芬
刘波
机构
[1] 哈尔滨理工大学化学与环境工程学院
关键词
双酚A; 肝脏毒性; 生殖毒性; 脂质过氧化损伤; 血睾屏障; 精子活力; 精子畸形率; 病理改变;
D O I
暂无
中图分类号
R114 [卫生毒理];
学科分类号
100235 [预防医学];
摘要
针对环境污染日益严重的现状,探讨了双酚A(BPA)对小鼠的肝脏毒性和生殖毒性的作用机制.对血浆和肝脏中的关键酶与精子畸形率进行了检测,并利用紫外可见分光光度计观察了肝脏和睾丸的病理改变.结果表明,BPA可以显著升高谷丙转氨酶(GPT)、谷草转氨酶(GOT)、碱性磷酸酶(AKP)和谷胱甘肽S转移酶(GST)的活力、丙二醛(MDA)和一氧化氮(NO)的含量以及精子畸形率.BPA可以显著降低超氧化物歧化酶(SOD)的活力,并改变了肝脏和睾丸组织的正常形态.BPA不仅可以对肝脏造成损伤,还可以透过血睾屏障损害睾丸的支持细胞和间质细胞,从而干扰精子的生长、发育和能量代谢过程,进而对生殖系统造成损伤.
引用
收藏
页码:710 / 715
页数:6
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