老年结直肠癌根治性切除患者的预后分析

被引：18

作者：

杨华 ^{[1
]}

肖刚 ^{[2
]}

汪欣 ^{[1
]}

机构：

[1] 北京大学第一医院普外科

[2] 北京医院普外科

来源：

中华老年医学杂志 | 2015年 / 04期

关键词：

结直肠肿瘤; 预后;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

摘要：

目的探讨老年结直肠癌患者根治切除术后的预后影响因素。方法回顾分析北大医院和北京医院2008年7月至2011年7月收治的年龄65岁以上, 行根治性结直肠癌切除术的416例患者的临床病理资料。采用Kaplan-Meier法进行生存分析, Log-rank检验进行生存率比较;应用Cox比例风险回归模型进行多因素生存分析。结果全组患者平均年龄(74.3±5.4)岁, Ⅰ、Ⅱ、Ⅲ期患者术后5年生存率分别为84.5%、77.3%、48.2%。单因素分析显示:年龄、美国麻醉师协会(ASA)评分、并发症、术前贫血、术前低蛋白血症、术后并发症、术前癌胚抗原(CEA)升高、术中出血量、围术期输血量、脉管癌栓、神经侵犯、肿瘤浸润深度、淋巴结转移、TNM分期及辅助治疗与预后相关。Cox多因素回归分析显示:年龄≥75岁、并发症、术后并发症、术前白蛋白<30 g/L、肿瘤浸润深度、淋巴结转移、TNM分期及辅助治疗是影响老年结直肠癌患者根治切除术预后的独立因素。结论老年结直肠癌患者行根治性切除术预后较好, 年龄≥75岁、并发症、术后并发症、术前白蛋白<30 g/L、肿瘤浸润深度、淋巴结转移、TNM分期及辅助化疗是影响其预后的独立因素。

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