呼吸道合胞病毒、副流感病毒3型毛细支气管炎患儿鼻咽分泌物趋化因子水平的比较

被引：5

作者：

董琳

陈小芳

周晓聪

林剑

李锦燕

机构：

[1] 温州医学院附属育英儿童医院呼吸科

来源：

实用儿科临床杂志 | 2007年 / 04期

关键词：

趋化因子; 鼻咽分泌物; 毛细支气管炎; 呼吸道合胞病毒; 副流感病毒3型;

D O I：

暂无

中图分类号：

R725.6 [小儿呼吸系及胸部疾病];

学科分类号：

100202 ;

摘要：

目的探讨趋化因子在呼吸道合胞病毒(RSV)及副流感病毒3型(PIV3)所致毛细支气管炎发病机制中的作用,比较两种病毒感染对其表达的影响。方法毛细支气管炎患儿40例,入院24 h内收集其鼻咽分泌物(NPS),应用直接免疫荧光法检测RSV和PIV3抗原。对照组为行心导管检查术和腹部手术的患儿14例。应用酶联免疫吸附试验(ELISA)测定NPS中调节活化正常T细胞表达及分泌的趋化因子(RANTES)、巨噬细胞炎性蛋白1α(MIP-1α)、IL-8水平。结果RSV阳性26例,PIV3阳性14例。PIV3感染患儿RANTES、MIP-1α及IL-8水平均高于RSV感染组,但差异无显著性(Z=0.551,0.357,0.169 Pa>0.05)。RSV及PIV3感染组RANTES、MIP-1α、IL-8水平均明显高于对照组(Z=3.65,4.10,4.22;Z=4.13,4.85,5.08 Pa<0.001)。RSV感染组RANTES、MIP-1α、IL-8间均呈显著正相关(P<0.01,0.05);PIV3组IL-8与MIP-1α及RANTES均呈显著正相关(Pa<0.01),RANTES与MIP-1α无相关性。结论RSV与PIV3感染有相似的免疫发病机制。趋化因子可能在其发病机制和呼吸道炎症中起重要作用。

引用

页码：253 / 255

页数：3

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