左西孟旦治疗心力衰竭的临床应用及安全性评价

被引:21
作者
程小敏
马淑梅
机构
[1] 中国医科大学附属盛京医院心内科
关键词
左西孟旦; 钙离子增敏剂; 心力衰竭;
D O I
暂无
中图分类号
R541.6 [血液循环衰竭]; R972 [心血管系统药物];
学科分类号
100117 [系统生物医学]; 100201 [内科学];
摘要
左西孟旦是一种新型钙离子增敏剂,除正性肌力作用,还具有扩血管、拮抗神经内分泌、抗炎、抗凋亡、改善微血管灌注作用,通过多种途径改善患者临床症状及远期预后,且不良反应较少,有望成为心力衰竭药物治疗的重要组成部分。本文对其作用机制及临床研究进展进行综述。
引用
收藏
页码:125 / 126
页数:2
相关论文
共 7 条
[1]
Effects of Levosimendan versus Dobutamine on inflammatory and apoptotic pathways in acutely decompensated chronic heart failure [J].
Adamopoulos, Stamatis ;
Parissis, John T. ;
Iliodromitis, Efstathios K. ;
Paraskevaidis, Ioannis ;
Tsiapras, Dimitrios ;
Farmakis, Dimitrios ;
Karatzas, Dimitrios ;
Gheorghiade, Mihai ;
Filippatos, Gerasimos S. ;
Kremastinos, Dimitrios T. .
AMERICAN JOURNAL OF CARDIOLOGY, 2006, 98 (01) :102-106
[2]
Pharmacology of New Agents for Acute Heart Failure Syndromes.[J].Mihai Gheorghiade;John R. Teerlink;Alexandre Mebazaa.The American Journal of Cardiology.2005, 6
[3]
Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake [J].
Michaels, AD ;
McKeown, B ;
Kostal, M ;
Vakharia, KT ;
Jordan, MV ;
Gerber, IL ;
Foster, E ;
Chatterjee, K .
CIRCULATION, 2005, 111 (12) :1504-1509
[4]
The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia [J].
Sonntag, S ;
Sundberg, S ;
Lehtonen, LA ;
Kleber, FX .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (12) :2177-2182
[5]
Levosimendan: first in a new class of inodilator for acute and chronic severe heart failure.[J].Cleland;Nikitin;McGowan.Expert Review of Cardiovascular Therapy.2004, 1
[6]
Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial [J].
Follath, F ;
Cleland, JGF ;
Just, H ;
Papp, JGY ;
Scholz, H ;
Peuhkurinen, K ;
Harjola, VP ;
Mitrovic, V ;
Abdalla, M ;
Sandell, EP ;
Lehtonen, L .
LANCET, 2002, 360 (9328) :196-202
[7]
Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure [J].
Nieminen, MS ;
Akkila, J ;
Hasenfuss, G ;
Kleber, FX ;
Lehtonen, LA ;
Mitrovic, V ;
Nyquist, O ;
Remme, WJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (06) :1903-1912