乙酰胆碱酯酶抑制剂类药物联合盐酸美金刚治疗阿尔茨海默病的效果分析

被引：14

作者：

邵自强

刘尊敬

汪仁斌

焦劲松

机构：

[1] 中日友好医院神经内科

来源：

中国临床保健杂志 | 2015年 / 18卷 / 05期

关键词：

阿尔茨海默病; 胆碱酯酶抑制剂; 美金刚;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

摘要：

目的探讨美金刚联合抗胆碱酶抑制剂治疗阿尔茨海默病(AD)的效果。方法选取110例患者参加研究,他们被分为美金刚组、美金刚+多奈哌齐、美金刚+卡巴拉汀、美金刚+加兰他敏和美金刚+石杉碱甲组,分别比较他们在治疗前和治疗后12周、24周的简易精神状态量表评分(MMSE)和AD协作学习-日常生活能力问卷评分(ADL)。结果所有患者的MMSE和ADL评分在治疗12和24周后与基线相比均明显改善,美金刚+石杉碱甲组改善最为明显。结论多奈哌齐、卡巴拉汀、加兰他敏、石杉碱甲联合使用美金刚,疗效好于单药治疗;石杉碱甲与美金刚联用,比其他Ch EI与美金刚联用,有更好的效果。

引用

页码：452 / 456

页数：5

共 20 条

[1]

Modulation of α7 Nicotinic Acetylcholine Receptor and Fibrillar Amyloid-β Interactions in Alzheimer's Disease Brain.[J].Ruiqing Ni;Amelia Marutle;Agneta Nordberg.Journal of Alzheimer's Disease.2012, 3

[2]

A phase II trial of huperzine A in mild to moderate Alzheimer disease [J].

Rafii, M. S. ;

Walsh, S. ;

Little, J. T. ;

Behan, K. ;

Reynolds, B. ;

Ward, C. ;

Jin, S. ;

Thomas, R. ;

Aisen, P. S. .

NEUROLOGY, 2011, 76 (16) :1389-1394

[3]

Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors [J].

Gilling, Kate E. ;

Jatzke, Claudia ;

Hechenberger, Mirko ;

Parsons, Chris G. .

NEUROPHARMACOLOGY, 2009, 56 (05) :866-875

[4]

Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease [J].

Geula, Changiz ;

Nagykery, Nicholas ;

Nicholas, Alexander ;

Wu, Chuang-Kuo .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2008, 67 (04) :309-318

[5]

Memantine treatment in patients with mild to moderate Alzheimer's disease: Results of a randomised, double-blind, placebo-controlled 6-month study [J].

Bakchine, S. ;

Loft, H. .

JOURNAL OF ALZHEIMERS DISEASE, 2008, 13 (01) :97-107

[6]

Forecasting the global burden of Alzheimer's disease [J].

Brookmeyer, Ron ;

Johnson, Elizabeth ;

Ziegler-Graham, Kathryn ;

Arrighi, H. Michael .

ALZHEIMERS & DEMENTIA, 2007, 3 (03) :186-191

[7]

Non-cholinergic effects of huperzine A: Beyond inhibition of acetylcholinesterase [J].

Zhang, Hai Yan ;

Yan, Han ;

Tang, Xi Can .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2008, 28 (02) :173-183

[8]

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease [J].

Schliebs, R. ;

Arendt, T. .

JOURNAL OF NEURAL TRANSMISSION, 2006, 113 (11) :1625-1644

[9]

Memantine treatment in mild to moderate Alzheimer disease: A 24-week randomized, controlled trial [J].

Peskind, Elaine R. ;

Potkin, Steven G. ;

Pomara, Nunzio ;

Ott, Brian R. ;

Graham, Stephen M. ;

Olin, Jason T. ;

McDonald, Scott .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2006, 14 (08) :704-715

[10]

Rivastigmine monotherapy and combination therapy with memantine in patients with moderately severe Alzheimer's disease who failed to benefit from previous cholinesterase inhibitor treatment.[J].T.Dantoine;S.Auriacombe;M.Sarazin;H.Becker;J‐JPere;I.Bourdeix.International Journal of Clinical Practice.2005, 1

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