VEGF、CD 62P和PMA与SLE患者易栓状态关系研究

被引:4
作者
何斌
顾健
石建霞
孙梅
张育
机构
[1] 江苏省扬州大学临床医学院血液科
关键词
系统性红斑狼疮; 易栓症; 血管内皮细胞生长因子(VEGF); 血小板表面CD 62p; 血小板-单核细胞聚合体(PMA);
D O I
暂无
中图分类号
R593.241 [];
学科分类号
1002 ; 100201 ;
摘要
目的观察系统性红斑狼疮(SLE)患者血管新生、血小板活化因子的临床意义。方法用流式细胞术测定血小板CD 62P、血小板-单核细胞聚合体(PMA),ELISA法测定血管内皮细胞生长因子(VEGF)。结果SLE活动期VEGF、血小板及炎症细胞的活化水平明显增高(P<0.05),稳定期该类闪子已基本恢复正常水平(P>0.05)。SLE患者治疗后VEGF、血小板及炎症细胞的活化程度抑制,与治疗前相比有显著差异(P<0.05)。结论SLE患者处于血栓前状态,易于发生动静脉血栓事件,早期发现临床征象可以及时干预治疗,改善预后。
引用
收藏
页码:157 / 159
页数:3
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