单核细胞趋化蛋白-1、组织因子和转化生长因子β1在慢性阻塞性肺疾病中的意义

被引：13

作者：

黄爱霞 ^{[1
,2
]}

机构：

[1] 上海交通大学附属第六人民医院南院

[2] 奉贤区中心医院呼吸科

来源：

热带医学杂志 | 2015年 / 15卷 / 01期

关键词：

单核细胞趋化蛋白-1; 组织因子; 转化生长因子β1; 慢性阻塞性肺疾病;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

目的观察慢性阻塞性肺疾病(COPD)患者单核细胞趋化蛋白-1(MCP-1)、组织因子(TF)和转化生长因子β1(TGF-β1)的变化。方法选择COPD患者135例,其中缓解期53例,急性加重期82例,根据肺功能分级将患者分为Ⅰ级22例、Ⅱ级27例和Ⅲ级33例。观察不同分期和不同肺功能分级COPD患者血清MCP-1、TF和TGF-β1水平变化。结果急性加重期和缓解期COPD患者的MCP-1、TF和TGF-β1水平明显高于对照组,而急性加重期患者的升高水平明显高于缓解期患者,差异均有统计学意义(P<0.05)。急性加重期COPD患者中,随着肺功能分级升高,患者的MCP-1、TF和TGF-β1水平相应升高。结论 MCP-1、TF和TGF-β1在COPD的发生发展中起到重要作用,检测其水平对于COPD的防治具有重要意义。

引用

页码：70 / 72

页数：3

共 8 条

[1]

探讨肺纤维化时表达单核细胞趋化蛋白-1的主要效应细胞 [J].

邓小玲 ;

许铭炎 ;

傅玉才 .

热带医学杂志, 2010, 10 (07) :767-769+787

[2]

Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population.[J]..Acta Pharmacologica Sinica.2005, 06

[3]

Decreased serum transforming growth factor-β1 concentration with aging is associated with the severity of emphysema in chronic obstructive pulmonary disease [J].

Kamio, Koichiro ;

Ishii, Takeo ;

Motegi, Takashi ;

Hattori, Kumiko ;

Kusunoki, Yuji ;

Azuma, Arata ;

Gemma, Akihiko ;

Kida, Kozui .

GERIATRICS & GERONTOLOGY INTERNATIONAL, 2013, 13 (04) :1069-1075

[4]

Expression of Connective Tissue Growth Factor and Bone Morphogenetic Protein-7 in Pseudomonas aeruginosa-induced Chronic Obstructive Pulmonary Disease in Rats [J].

Wen, Wen ;

Wang, Ai-min ;

Liu, De-ling ;

Zhang, Ya-bin ;

Yao, Li-qing ;

Lai, Guo-xiang .

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2013, 10 (06) :657-666

[5]

Activated factor XI and tissue factor in chronic obstructive pulmonary disease: Links with inflammation and thrombin generation.[J].Milosz Jankowski;Anetta Undas;Przemyslaw Kaczmarek;Saulius Butenas.Thrombosis Research.2010, 3

[6]

Circulating tissue factor procoagulant activity is elevated in stable moderate to severe chronic obstructive pulmonary disease.[J].Vijender Reddy Vaidyula;Gerard J. Criner;Carla Grabianowski;A. Koneti Rao.Thrombosis Research.2008, 3

[7]

Exhaled breath condensate levels of 8-isoprostane; growth related oncogene α and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease.[J].Fanny W.S. Ko;Christine Y.K. Lau;Ting F. Leung;Gary W.K. Wong;Christopher W.K. Lam;David S.C. Hui.Respiratory Medicine.2005, 4

[8]

Tumor necrosis factor - alpha serum levels, weight loss and tissue oxygenation in chronic obstructive pulmonary disease [J].

Pitsiou, G ;

Kyriazis, G ;

Hatzizisi, O ;

Argyropoulou, P ;

Mavrofridis, E ;

Patakas, D .

RESPIRATORY MEDICINE, 2002, 96 (08) :594-598

← 1 →