瑞舒伐他汀对颈动脉粥样硬化患者颈动脉内中膜厚度及血清炎症因子的影响

被引：19

作者：

华先平 ^{[1
]}

杨勇 ^{[1
]}

娄国平 ^{[2
]}

曹政 ^{[1
]}

吴瑞霞 ^{[1
]}

陈彬 ^{[1
]}

陈平英 ^{[1
]}

机构：

[1] 湖北医药学院附属太和医院心内科区

[2] 湖北医药学院附属太和医院检验科

来源：

中国循环杂志 | 2011年 / 26卷 / 03期

关键词：

颈动脉; 粥样硬化; 炎症; 瑞舒伐他汀; 高敏C反应蛋白; 基质金属蛋白酶-9;

D O I：

暂无

中图分类号：

R543.4 [颈动、静脉疾病];

学科分类号：

100201 [内科学];

摘要：

目的:观察瑞舒伐他汀对颈动脉粥样硬化患者颈动脉内中膜厚度(IMT)及血清炎症因子的影响,并了解瑞舒伐他汀出现临床治疗效果的时间点。方法:同期随机入选颈动脉粥样硬化患者81例为治疗组(口服瑞舒伐他汀10 mg/d),颈动脉内膜正常者52例为对照组,所有入选者低脂肪饮食。治疗前和治疗后6个月每月末检测血清低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、高敏C反应蛋白(hsCRP)及基质金属蛋白酶-9(MMP-9)浓度,并经超声检测颈动脉IMT。结果:治疗前治疗组血清TC、TG、LDL-C、hsCRP和MMP-9浓度及颈动脉IMT均高于对照组(P<0.05～0.01),HDL-C低于对照组(P<0.05),差异均有统计学意义。与治疗前比较,治疗组各观察指标从开始出现显著差异的时间点:从治疗后1个月开始血清TC、LDL-C、hsCRP及MMP-9明显下降,从2个月开始TG明显下降,从6个月开始颈动脉IMT明显降低,至6个月末均明显下降(P<0.05～0.01);从3个月开始HDL-C明显升高,至6个月末均明显升高(P<0.05～0.01),差异均有统计学意义。结论:瑞舒伐他汀具有良好的调脂、抗炎和抗颈动脉粥样硬化作用,治疗6个月后颈动脉IMT明显降低。

引用

页码：198 / 201

页数：4

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