盐酸安非他酮缓释片治疗抑郁症的Ⅱ期临床研究

被引:1
作者
王继才
熊鹏
欧阳虹
李文昱
许秀峰
机构
[1] 昆明医学院第一附属医院精神科
关键词
抑郁症; 盐酸安非他酮; 氟西汀; 双盲法; 对比疗效;
D O I
暂无
中图分类号
R749.4 [情感性精神病];
学科分类号
100205 ;
摘要
目的评价盐酸安非他酮缓释片治疗轻中度抑郁症的临床疗效和安全性。方法对符合《CCMD-3》抑郁症诊断标准的66例抑郁症患者进行盐酸安非他酮缓释片和氟西汀的对照研究,其中盐酸安非他酮缓释片组34例(300mg/d),氟西汀组32例(20mg/d),共治疗6周。采用汉密尔顿抑郁量表(HAMD),汉密尔顿焦虑量表(HAMA),临床总体评定量表(CGI)评定临床疗效,副反应量表(Tess)评定不良反应。结果经6w治疗后,盐酸安非他酮缓释片治疗总有效率为76.47%,氟西汀组为75.00%,两组比较,差异无显著性(P>0.05)。两组的HAMD,HAMA评分治疗前后相比较差异有高度显著性(P<0.01)。不良反应分析,两组药物不良反应的发生率无显著性差异(P>0.05),常见的不良反应有恶心、口干、头昏、失眠、出汗、食欲减退、便秘等。结论盐酸安非他酮缓释片治疗抑郁症安全有效。
引用
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页码:538 / 542
页数:5
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